Drinking baking soda ?

Discussion in 'Serious Discussion' started by parrish, Jun 12, 2018.

  1. parrish

    parrish MDL Novice

    Oct 16, 2016
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    Drinking baking soda ?

    Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease


    Source:

    Medical College of Georgia at Augusta University


    Summary:

    A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say.



    They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, scientists report.


    A daily dose of baking soda may help reduce the destructive inflammation of autoimmune diseases like rheumatoid arthritis, scientists say.


    They have some of the first evidence of how the cheap, over-the-counter antacid can encourage our spleen to promote instead an anti-inflammatory environment that could be therapeutic in the face of inflammatory disease, Medical College of Georgia scientists report in the Journal of Immunology.



    They have shown that when rats or healthy people drink a solution of baking soda, or sodium bicarbonate, it becomes a trigger for the stomach to make more acid to digest the next meal and for little-studied mesothelial cells sitting on the spleen to tell the fist-sized organ that there's no need to mount a protective immune response.



    "It's most likely a hamburger not a bacterial infection," is basically the message, says Dr. Paul O'Connor, renal physiologist in the MCG Department of Physiology at Augusta University and the study's corresponding author.


    Mesothelial cells line body cavities, like the one that contains our digestive tract, and they also cover the exterior of our organs to quite literally keep them from rubbing together.



    About a decade ago, it was found that these cells also provide another level of protection.



    They have little fingers, called microvilli, that sense the environment, and warn the organs they cover that there is an invader and an immune response is needed.



    Drinking baking soda, the MCG scientists think, tells the spleen -- which is part of the immune system, acts like a big blood filter and is where some white blood cells, like macrophages, are stored -- to go easy on the immune response.



    "Certainly drinking bicarbonate affects the spleen and we think it's through the mesothelial cells," O'Connor says.


    The conversation, which occurs with the help of the chemical messenger acetylcholine, appears to promote a landscape that shifts against inflammation, they report.



    In the spleen, as well as the blood and kidneys, they found after drinking water with baking soda for two weeks, the population of immune cells called macrophages, shifted from primarily those that promote inflammation, called M1, to those that reduce it, called M2.



    Macrophages, perhaps best known for their ability to consume garbage in the body like debris from injured or dead cells, are early arrivers to a call for an immune response.



    In the case of the lab animals, the problems were hypertension and chronic kidney disease, problems which got O'Connor's lab thinking about baking soda.



    One of the many functions of the kidneys is balancing important compounds like acid, potassium and sodium.



    With kidney disease, there is impaired kidney function and one of the resulting problems can be that the blood becomes too acidic, O'Connor says.



    Significant consequences can include increased risk of cardiovascular disease and osteoporosis.



    "It sets the whole system up to fail basically," O'Connor says.



    Clinical trials have shown that a daily dose of baking soda can not only reduce acidity but actually slow progression of the kidney disease, and it's now a therapy offered to patients.



    "We started thinking, how does baking soda slow progression of kidney disease?" O'Connor says.



    That's when the anti-inflammatory impact began to unfold as they saw reduced numbers of M1s and increased M2s in their kidney disease model after consuming the common compound.



    When they looked at a rat model without actual kidney damage, they saw the same response.



    So the basic scientists worked with the investigators at MCG's Georgia Prevention Institute to bring in healthy medical students who drank baking soda in a bottle of water and also had a similar response.



    "The shift from inflammatory to an anti-inflammatory profile is happening everywhere," O'Connor says.



    "We saw it in the kidneys, we saw it in the spleen, now we see it in the peripheral blood."



    The shifting landscape, he says, is likely due to increased conversion of some of the proinflammatory cells to anti-inflammatory ones coupled with actual production of more anti-inflammatory macrophages.



    The scientists also saw a shift in other immune cell types, like more regulatory T cells, which generally drive down the immune response and help keep the immune system from attacking our own tissues.



    That anti-inflammatory shift was sustained for at least four hours in humans and three days in rats.



    The shift ties back to the mesothelial cells and their conversations with our spleen with the help of acetylcholine.



    Part of the new information about mesothelial cells is that they are neuron-like, but not neurons O'Connor is quick to clarify.



    "We think the cholinergic (acetylcholine) signals that we know mediate this anti-inflammatory response aren't coming directly from the vagal nerve innervating the spleen, but from the mesothelial cells that form these connections to the spleen," O'Connor says.



    In fact, when they cut the vagal nerve, a big cranial nerve that starts in the brain and reaches into the heart, lungs and gut to help control things like a constant heart rate and food digestion, it did not impact the mesothelial cells' neuron-like behavior.



    The affect, it appears, was more local because just touching the spleen did have an effect.



    When they removed or even just moved the spleen, it broke the fragile mesothelial connections and the anti-inflammatory response was lost, O'Connor says.



    In fact, when they only slightly moved the spleen as might occur in surgery, the previously smooth covering of mesothelial cells became lumpier and changed colors.



    "We think this helps explain the cholinergic (acetylcholine) anti-inflammatory response that people have been studying for a long time," O'Connor says.



    Studies are currently underway at other institutions that, much like vagal nerve stimulation for seizures, electrically stimulate the vagal nerve to tamp down the immune response in people with rheumatoid arthritis.



    While there is no known direct connection between the vagal nerve and the spleen -- and O'Connor and his team looked again for one -- the treatment also attenuates inflammation and disease severity in rheumatoid arthritis, researchers at the Feinstein Institute for Medical Research reported in 2016 in the journal Proceedings of the National Academy of Sciences.



    O'Connor hopes drinking baking soda can one day produce similar results for people with autoimmune disease.



    "You are not really turning anything off or on, you are just pushing it toward one side by giving an anti-inflammatory stimulus," he says, in this case, away from harmful inflammation.



    "It's potentially a really safe way to treat inflammatory disease."



    The spleen also got bigger with consuming baking soda, the scientists think because of the anti-inflammatory stimulus it produces.



    Infection also can increase spleen size and physicians often palpate the spleen when concerned about a big infection.


    Other cells besides neurons are known to use the chemical communicator acetylcholine.



    Baking soda also interact with acidic ingredients like buttermilk and cocoa in cakes and other baked goods to help the batter expand and, along with heat from the oven, to rise.



    It can also help raise the pH in pools, is found in antacids and can help clean your teeth and tub.



    The research was funded by the National Institutes of Health.



    Story Source:


    Materials provided by Medical College of Georgia at Augusta University. Original written by Toni Baker. Note: Content may be edited for style and length.


    Journal Reference:



    Sarah C. Ray, Babak Baban, Matthew A. Tucker, Alec J. Seaton, Kyu Chul Chang, Elinor C. Mannon, Jingping Sun, Bansari Patel, Katie Wilson, Jacqueline B. Musall, Hiram Ocasio, Debra Irsik, Jessica A. Filosa, Jennifer C. Sullivan, Brendan Marshall, Ryan A. Harris, Paul M. O’Connor. Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells.


    The Journal of Immunology, 2018; ji1701605 DOI: 10.4049/jimmunol.1701605



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    Medical College of Georgia at Augusta University. "Drinking baking soda could be an inexpensive, safe way to combat autoimmune disease." ScienceDaily. ScienceDaily, 25 April 2018.



    Code:
    www.sciencedaily.com/releases/2018/04/180425093745.htm
     
  2. sml156

    sml156 MDL Member

    Sep 8, 2009
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    Is 4Chan offline today
     
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  3. Yen

    Yen Admin
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    #3 Yen, Jun 13, 2018
    Last edited: Jun 13, 2018
    This could be considered as supporter of alkaline water drinking....but....
    Baking soda with real presence has capacity, 'alkaline water' has not.

    And a shift from predominantly M1 (inflammatory) to M2 (regulatory) phenotypes is a vague statement. It's an isolated phenomenon of a complex process chain and can be misinterpreted.

    Neutralization of an actually harmful liquid (it would digest our organs if leaked- ever had a gastritis?) can lead to temporary down-regulation of alert systems....and......check yourself:

    The headline (which is adventurous):

    Compared to the explanation
    The next daily dose would neutralize the acid again. It's just the system that tries to compensate the effect of bicarbonate by producing more acid. It's most likely that the observed effects (shift from predominantly M1 (inflammatory) to M2 (regulatory) phenotypes) will be reversed sooner or later. Human body gets used to the fact that here is some acid lost by neutralization....
     
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  4. Michaela Joy

    Michaela Joy MDL Crazy Lady

    Jul 26, 2012
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    Yeah. They're offline. The admins drank baking soda and got stomach parasites. :moon:
     
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  5. Yen

    Yen Admin
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    I wonder what would happen when skipping the first day and getting even more acidic foods the 'next day' lol...
    Should be the perfect cure then?! :D

    If I have got this right the cause that there's no need to mount a protective immune response is the trigger to make more acid....the 'next day'.

    No seriously. One cannot stimulate the acid production every day by eating bicarbonate. I think the trick is to have a balanced nutrition...where there is one day with more acidic foods and days with far less.
     
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  6. Joe C

    Joe C MDL Guru

    Jan 12, 2012
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    I don't know about all that other stuff mentioned here about baking soda, but it works great as a substitute for antacid when I get heartburn. Just add about a teaspoon in 1/2 glass of water, just like Rolaids!
     
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  7. macnavarra

    macnavarra MDL Member

    Nov 13, 2017
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    In my opinion baking soda is good to clean the fat- soluble vitamins In vegetables stew. :chempoff:
     
  8. Michaela Joy

    Michaela Joy MDL Crazy Lady

    Jul 26, 2012
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    If you want to have fun with Baking soda, then get food grade citric acid. Mix them in almost equal parts, (about a teaspoon each)

    Put this in a glass of water. The result: Alka seltzer without the aspirin. :)

    https://www.alkaseltzer.com/products/gold/
     
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  9. pf100

    pf100 MDL Expert

    Oct 22, 2010
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  10. Michaela Joy

    Michaela Joy MDL Crazy Lady

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    @pf100: LOL I suppose you could drink that volcano... But I suspect you'll be burping for hours. :D
     
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  11. lewcass

    lewcass MDL Senior Member

    Mar 10, 2018
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    #11 lewcass, Jun 14, 2018
    Last edited: Jun 14, 2018
    Drink that and you will fart Midnight In Moscow in its entirety and make Kenny Ball look like a beginner :haha:



    Alubum version, way better :)

     
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  12. Michaela Joy

    Michaela Joy MDL Crazy Lady

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    I purposely stayed away from that end. :nono:

    But you might be right. :g:
     
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  13. lewcass

    lewcass MDL Senior Member

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    Farting is a fact of life and a natural bodily function, just like burping. Now if i talked about lighting them then thats a different matter :haha:
     
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  14. Yen

    Yen Admin
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    Yes, this makes perfect sense. Sodium bicarbonate (baking soda) neutralizes a part of the stomach acid. Rolaids is Calcium carbonate plus Magnesium hydroxide. Both also neutralize.
    Rolaids has the advantage that it supplies the body with additional Magnesium and Calcium which is actually better than additional Sodium....(we get enough Sodium from foods).

    It's rapid-acting against gastric reflux.

    Lol. Those colors look unhealthy, though.
    It's been one of my first experiments when I was a kid......the produced foam can be used to extinguish fire.
    I used baking soda and tartaric acid, though.

    You could also buy that mixture with some different flavours as cubes.
    We made that as a dare. Put one cube in the mouth and close it tightly. The one who could stand it the longest time had won.

    It mostly ended with foam coming out of the nose and heavy coughing lol, was fun.:D
     
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  15. totalbeliever

    totalbeliever MDL Junior Member

    Oct 22, 2015
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    It's my first time to know about this but its good to hear that it helps an autoimmune disease.
     
  16. TKnuckles

    TKnuckles MDL Junior Member

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  17. MS_User

    MS_User MDL Guru

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    i wouldnt drink that s**t.
     
  18. andy.tay70

    andy.tay70 MDL Junior Member

    Dec 15, 2013
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    Bottom burping too!