look for the services names, wdnissvc for example and deactivate it in: HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services start: 4 (disabled)
Disable using group policy. Use the Windows key + R keyboard shortcut to open the Run command. Type gpedit.msc Computer Configuration > Administrative Templates > Windows Components > Windows Defender Antivirus Double-click the Turn off Windows Defender Antivirus policy. Select Enabled.
@JWilly there are no group policy on a Home version of W10 except if you hack it with reg keys somewhere on the net.