I've not been able to find anything about this subject here nor googling around. As many of us I have a relatively small ssd + secondary traditional Hard Drives (organized in a Raid5 array in my case). With Win 7 and 8 I'd been able to move my main user account on D:, a bigger and safer location, but it looks like it is no more possible with Win 10. If I only move my main user account, I loose the start button (if I left-click on it nothing shows up, if I right-click the relevant menu appears) and if I click on internet explorer (or whatever it's called now), its window appears for a while and then shuts down. If I try to change the new users default location, I am able to create an account, but when I try to login in the new account Windows says: The User Profile Service failed the sign-in. User profile cannot be loaded I used the registry tricks to try to do that but it looks that something more has to be done to accomplish the task. Any suggestion?