I'm working on a portable tool for automating AV/Malware scanning and cleaning using AutoIT and all the free AV/Malware scanners out there. Here's my current results from the research & testing I've done: ClamWin Can be fully automated using CLI options Type: CLI Emsisoft a2cmd Can be fully automated using CLI options Initial download is large (>150MB) Type: CLI VIPRE Rescue Scanner Can be fully automated EXCEPT for 'detect only' which it doesn't support Initial download is very large (>200MB) Type: CLI Spybot 1.6.2 Can be fully automated EXCEPT location of log files Type: GUI Trendmicro Sysclean Can be fully automated but must tweak batch file for correct download locations Type: CLI/GUI Norman Malware Cleaner Can be fully automated using CLI options Initial download is very large (>300MB) Type: GUI McAfee Stinger32 Can be fully automated using CLI options EXCEPT writing to a specific log file Type: GUI Comodo Cleaning Essentials Can be fully automated EXCEPT location of log files Type: GUI Note: "Full automation" requires the ability to redirect log files to a location the automation tool can parse, as well as being able to automatically update the program. And here are the scanners that require Wrappers written in something like AutoIT: Super Anti-Spyware Portable (mostly complete) Spybot Portable 2.x (mostly complete) Kaspersky Virus Removal Tool Initial download is large (>100MB) Malwarebytes Anti-Malware Portable (mostly complete) Microsoft Safety Scanner Initial download is large (>150MB) Norton Power Eraser Norton Security Scan Full definition files are ridiculously large (>1GB!) Sysinternals AutoRuns* It does have a CLI version but I'm having trouble figuring it out... GMER Trendmicro Housecall Dr. Web CureIT! Initial download is large (>100MB) Once the Wrappers are complete they will be standalone products, meaning you can use them by themselves with parameters you pass them (such as '/QUICK', '/CLEAN', etc.). Finally, here are some portable scanners I can't figure out how to use for scanning Windows offline (IE they don't accept a custom path to scan): Sophos Virus Removal Tool Initial download is large (>100MB) Junkware Removal Tool Hitman Pro Can't do removals without a license anyway ComboFix herdProtectPortable AdwCleaner CAN be redirected using "RunScanner" tool TDSSKiller The lack of redirection with herdProtectPortable is especially unfortunate, since that's a multi-AV cloud scanner which seems to work decently.