My sense is that since Windows 7, Microsoft OS has been pretty good with optimized TCP/IP settings. I played around something months ago, don't recall the name, it did nothing for me. And if this was a big issue, wouldn't there be a lot of threads on MDL about it?
Same as all so called Optimizers usually garbage, there are plenty of information sites where you can find information are regards to tweaking your internet. But usually best place to start is with your ISP if they have support forums, and another thing is most tweaks or more to the point settings can be done through cmd window.