Sorry for this but I spoke too soon Following this guide will do nothing because ME part in UEFI will not be updated. I even bricked my mobo experimenting further, flashback does not help and the only way would be to get the bios chip flashed outside of mobo. I ordered a brand new x99a instead and will not pursue this issue until someone else comes up with a safe solution. Hi, I wrote this guide for myself but felt that maybe someone else can make use of it. My motherboard is a ASUS X99-A and as far as I can tell I no longer have a working Intel ME after following the following steps =) Spectre and Meldown in all glory but Intel ME is for me a much greater concern. I also successfully added Intel Microcode (Intel Core i7-5930K Haswell-E/EP 306F2:3B) with UBU to mitigate Spectre successfully in another guide but my computer was noticeably slower and behaved strangely in some situations, for instance in Windows 10 1709 with all patches applied and my ASUS Radeon RX 480 changing resolutions and or displays took up to 30 seconds with black screens and a lot of flickering, if not a BSOD with black screen and no text so I removed that Microcode. This Intel ME me_cleaner guide however works flawlessly so far =) This guide is only for the daring, and know this: your computer might brick if you do this improperly and the warranty will be void. Good luck! 1. Download and install Python 2.7.x: www*python.org/downloads/ 2. Download me_cleaner.py: github*com/corna/me_cleaner and put it in your Python root dir C:\Python27\ 3. Download UBU: www*win-raid.com/t154f16-Tool-Guide-News-quot-UEFI-BIOS-Updater-quot-UBU.html and extract it to C:\UBU\ 4. Download a copy of your motherboards latest bios and extract it to your UBU folder. 5. Run UBU.bat 6. When UBU has finished getting info from your bios while UBU is still running with the options menu shown, move the bios.bin found in your UBU folder to C:\Python27\ (do not exit UBU yet) 7. Check if your bios is compatible with me_cleaner: - Open CMD with admin privileges and cd to your Python dir, type: Code: cd c:\python27 and then: Code: python.exe me_cleaner.py -c bios.bin it should say something like this: Code: Full image detected The ME/TXE region goes from 0x3000 to 0x180000 Found FPT header at 0x3010 Found 20 partition(s) Found FTPR header: FTPR partition spans from 0x47000 to 0xcf000 ME/TXE firmware version 22.214.171.1242 Public key match: Intel ME, firmware versions 9.0.x.x, 9.1.x.x Checking the FTPR RSA signature... VALID 8. Run me_cleaner on your bios: - Type: Code: python.exe me_cleaner.py -S -O bios.bin.mod bios.bin 9. If no error messages were shown, you now have a cleaned bios named bios.bin.mod in C:\Python27 10. Move the file bios.bin.mod to C:\UBU and rename it bios.bin 11. Exit UBU with 0 and then select "1 - Rename to ASUS USB BIOS Flashback" 12. You will now have a .cap file that you can flash with ASUS USB BIOS Flashback that is cleaned from Intel ME. Please comment with success or failure and what motherboard/CPU you have. Question: Should I remove (uninstall the drivers) or disable the Intel ME device in Device Manager? Also: What is the purpose and security concerns of ASUS Probe II Sense Drivers (AXSP/ATKEX, Io/AsIO64)? I am not using any ASUS programs at all and will not overclock my motherboard.