To put it short I really find it baffling when I can't open encrypted external hard disk drive in Safe Mode in Windows operating system. Every time, I try to open it the Windows displays warning message dialog of '' This driver is not accessible'' as if it is a bad drive. The same encrypted drive would open in normal Windows 10 mode with my password. The reason I am so curious about it is that in one time I have an issue with a system infected with USB virus and running application on it becomes very difficult because it has a deep freeze security installed to it. After removing the USB virus at reboot it will return again thereby creating a loop - in Safe Mode things seem to work fine. Opening a program I need to use at that point from my external hard drive is not possible due to the inaccessibility of the drive. The whole process of running the program becomes tedious and at the end I have to abandon it. I don't know if anybody know any mean on how to make it work, to open encrypted external hard disk drive in Safe Mode in Windows 10 or other Windows OS and copy files from it without removing the encryption. Any idea is highly welcome.