I used it when i had 16GB (2x 8GB kit) + 8GB (2x 4GB kit) ram onboard, on my previous mainboard. The 2 x 2 different ram units didn't work fine together (and i believe it wrecked my old mainboard) and now i'm back to 16GB ram (the 8GB units won't work anymore). As soon as i have re-installed windows, i'm going to give it another try with ramdisks for servicing.
Another couple of concerns crossed my mind: Can RAM chips really stand the overhead? How are RAM chips different against SSD chips to stand thousands of reads and writes?
If i understand correctly computer memory chips are more resilient than SSD memory because computer ram is volatile which all data is lost when power lost. Plus it is designed to last a long time, i have some memory in the test pc that is now close to 9 yrs old and its been in used every day for about as long! The NAND type in SSD's are nonvolatile which obviously keeps data retained also due to the way they are made only last x amount of writes as we know. As long as you have a decent amount of system ram to allow for a good sized ramdisk for your needs then you should be good to go
I still say just get an SSD. So what if you kill it. Just kill it within warranty & your fine! I think a ramdisk would be too small if your mounting, updating, exporting, temp files, etc - unless you've got the cash of course...