I have not used Corel Draw myself and so I have no idea if it will work on my system. Which version of Corel Draw are you referring to? According to the Corel Draw system requirements , the current version (2025) requires Windows 11 (22H2 or later) or Windows 10 (22H2 or later), so it may not work with Windows 10 LTSC 2021 since it is based on Windows 10 21H2. Apparently Corel also follows Microsoft support policies when it comes to Corel Draw. The previous version 2023 requires Windows 10 21H2 or later, so this is the version that should work with Windows 10 LTSC 2021.
been using LTSB/C since LTSB 2015/2016; I have LTSC 2021 installed on my bedroom hewlett-packard desktop pc and on an old 2007 Dell Inspiron laptop and they've been running well haven't tested Win11 LTSC 2024 yet since those old PCs I'm using don't use cpus with sse4.2 support