Coronavirus | Discussion

Discussion in 'Serious Discussion' started by Deleted member 1254778, Feb 28, 2020.

  1. case-sensitive

    case-sensitive MDL Expert

    Nov 7, 2013
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    Mask requirement: poison on the face

    It was the fear of the mutants of the Sars-CoV2 virus that led the prime ministers to tighten the mask requirement again in mid-January. Since then we have had to wear FFP2 or surgical masks in shops and public transport. And it is precisely these masks that are not suitable for this application, because "what we put through our mouth and nose is actually hazardous waste," says Prof. Michael Braungart, the scientific director of the Hamburg Environmental Institute.

    https://www.heise.de/tp/features/Maskenpflicht-Gift-im-Gesicht-5055786.html

    https://www.heise.de/forum/Telepoli...ich-getragen-zu-werden/posting-38390641/show/
     
  2. Yen

    Yen Admin
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    #2062 Yen, Feb 19, 2021
    Last edited: Feb 19, 2021
    @gorski It seems now is crystallizing what I have tried to illustrate. We have to let go the idea of absolutes. "It is protective against SARS-CoV-2."
    SARS-CoV-2 is no absolute term.

    The vaccine makers have to choose a certain sequence of the S-Protein while SARS-CoV-2 is continuing to mutate. The current rate is 2 amino acids per month.

    I have for example read the AstraZeneca studies about efficacy. Besides of their 'accident' to have used half dose / single booster at one cohort and single dose / single dose at another they have found lots of different values of efficacy.
    I got headache while reading.

    We only get some rationality in this when understanding it in terms of probability of protection.
    Each change at the S-protein and even more at the RBD (receptor binding domain) of the virus results in lesser efficacy.

    All COVID-19 vaccines besides of the traditional ones which use inactivated virus do target the S-protein!

    The mRNA based vaccines such as Pfiizer and Moderna seem to have the best ability to provoke an immune response.
    Vector viral vaccines such as AstraZeneca and J&J seem to have lesser efficacy in general.

    Traditional vaccines such as Sinopharm and Covaxin (inactivated virus) seem to have also a little lesser one than mRNA ALTHOUGH those makers are not very transparent with their data.

    Pfizer has an issue with allergic reactions, AstraZeneca has generally more side effects (fatigue, fever, headache, joint pain). And those 2 cases of a severe adverse effect which caused them to halt the study one time.

    The mutation issue seems to affect AstraZeneca a bit more due to the lesser initial efficacy. It is seemingly useless against the SA variant already.

    But!
    What we 'keep' anyway is a protection against severe COVID-19 progresses.
    In other words: When the virus is continuing to 'mutate away' from the vaccines original chosen target sequence the probability to get symptoms by an infection also increases BUT not yet to an amount where it can reach that lethality by COVID-19 we would have without vaccination.

    It is a dynamic process of changing probabilities. Means efficacy rates.
    The motor is mutation.
    The 'confusions' are due to the fact that we actually have shortened all the clinical trial phases and we now have many things still open at ongoing public phase IV to be clarified.

    That's why! (Besides of the statistical issues any study has due to the fact that you cannot infect the participants of a study deliberately with a certain variant / mutation to get clearer data for given ethical reasons.)

    It is important to have alternatives / additional drugs to the vaccines, which do have an independent MOA, independent to the variants, urgently!
     
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  3. Tiger-1

    Tiger-1 MDL Guru

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  4. Yen

    Yen Admin
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    Yesterday there was in the news (Germany) that lots of people do not realize their 'vaccination date' when getting AstraZeneca vaccine.
    Their reasons are: Confusion of efficacy rates and high amount of side effects which cause even inability to work a few days after the vaccination. Some had breathlessness, some had numbness in the arm where the shot has been made (could not even lift the arm anymore and so on).

    There are even some YouTube reports: How I felt after I have got AstraZeneca...one paramedic even thought after one night of sleep he's got a stroke!
     
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  5. Tiger-1

    Tiger-1 MDL Guru

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    Jesus...;):fear2:
     
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  6. case-sensitive

    case-sensitive MDL Expert

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    Is adenovirus DNA built into the genome?

    AstraZeneca's vaccine candidate is based on adenoviruses. With them, foreign genetic material gets into the cell nucleus. It could be built into the human genome. But how likely is that?

    The skepticism about the new corona vaccines was there faster than their approval. Gene changes, so it was circulating among vaccination skeptics and opponents, could cause the new vaccines. With the first approved vaccines, these fears could easily be allayed, a basic knowledge of biology is sufficient. With the third vaccine approved in the EU, that of AstraZeneca, the situation is by no means so clear.

    https://www.spektrum.de/news/vektor...3545962?utm_source=pocket-newtab-global-de-DE
     
  7. Yen

    Yen Admin
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    #2067 Yen, Feb 19, 2021
    Last edited: Feb 19, 2021
    @case-sensitive Interesting link. Thanks for that.

    Yes DNA insertions of adeno viruses's DNA can happen in rare cases.
    There are several studies in which they could prove that.
    Also the experts can only say:" I don't think it's an issue. We get adeno virus wild infections, humans are used to."

    But the vaccine makers are using a DNA engineered version in order to inject the S-protein DNA bit into the nucleus AND in order to make it replication-incompetent.

    There (nucleus) it's transcribed to mRNA which then leaves the nucleus. It moves to the ribosome where it then makes the S-protein. The S-protein then gets 'shredded' into pieces and these are presented on the cell's surface usually on MHC II. (If they are APC = antigen presenting cells, immune cells like macrophages, dendritic cells).

    A naive T-cell then connects to MHC II and either becomes a T-helper 1 or T-helper 2 cell (Th2 pathway--> B-cells--->antibodies, Th1 pathway-->cytotoxic T-cells AKA T-killer cells).

    IMHO the solution would have been simple.
    At the preclinical studies they should have tested it if they can manage to make ChAdOx1 (the virus used by AstraZeneca) inserting its DNA into human cell's genome. A in vitro test would have been fine.


    Additional vector viral based vaccines:

    Used by: Sputnik V adeno virus type 26 used in the first shot. The second shot is another adeno virus ad5. The Russians use 2 different viruses at initial and booster shot!

    Interestingly the J&J vaccine uses the first one ad26 virus as a single shot.
    Cansino uses the second one ad5 based vector only.
    ad5 and ad26 are human adeno viruses whereas ChAdOx1 (Ch = chimpansee).

    Sources of concerns: (both especially related to type 5 adenoviruses, though. Anyway we are speaking of the same family).

    "Use of adenovirus type-5 vectored vaccines: a cautionary tale"
    https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)32156-5/fulltext

    "Adenovirus as an integrating vector"
    https://pubmed.ncbi.nlm.nih.gov/12109211/

     
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  8. case-sensitive

    case-sensitive MDL Expert

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    In a study from the university hospital hamburg ...... so far in hamburg ...... 735 deaths in conection with corona . The oldest person that died was 101 . The youngest 29 . 75 % of the people that died were over 76 . The average age of people that died was 83 . 7 people under 50 died . Most of the people that died were already ill with other illnesses like chronic kidney problems , high blood preasure or COPD . 20 % were over weight

    https://www.welt.de/regionales/hamb...aran-sind-Hamburgs-Corona-Tote-gestorben.html


    Austrian ski resort study shows longer-lasting COVID-19 immunity

    A majority of residents at the Ischgl ski resort in Austria who contracted COVID-19 last year still have immunity eight months after they were infected, according to a study by The Medical University of Innsbruck. The resort is believed to have been the scene of Europe's first coronavirus '"super-spreader" event. Researchers found close to 90% of people who tested positive in April still had antibodies for the virus in November. Austria’s main public health agency AGES, believes the Ischgl outbreak, in which thousands of people from across Europe were infected, began in February last year before the first cases in Austria were detected. The study is believed to be one of the largest-ever carried out over the longest period of time. Researchers say it will help answer the question of how long immunity lasts after infection. Dr Wegene Tamire Borena led the research. She says the study's findings are supported by similar research carried out elsewhere. "What we found correlates strongly with the findings of the few other studies coming out, like in England weeks ago, which found 88% of people still have immunity after six months," she says.

    https://www.euronews.com/2021/02/18/austrian-ski-resort-study-shows-longer-lasting-covid-19-immunity
     
  9. Mr.X

    Mr.X MDL Guru

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  10. gorski

    gorski MDL Guru

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    I'll have what he is having:oops: - it's seems like a ball in his head...:p and I could do with some of that, just about now...:rolleyes:
     
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  11. gorski

    gorski MDL Guru

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    Btw, after a good chat with a doc, given I am in a "vulnerable group", I had an mRNA vaccine...:oops: No hard-on yet, sadly...:rolleyes::D only where the jab went in, that is hard and painful, as opposed to another Pfizer product of some renown...:rolleyes::oops::p But no other symptoms, no pain, headache, no allergic reaction, they had me monitored for some 20 minutes afterwards, so far (second day afterwards) so good...:cool:

    EDIT: I just tried it again and the place where I was given the vaccine is also fine now, so... we'll see... ;)
     
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  12. Mr.X

    Mr.X MDL Guru

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    Why vulnerable? Are you very old or comorbid? Are you nuts or not NOW? :p
     
  13. gorski

    gorski MDL Guru

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    Get a grip, ffs,,,,
     
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  14. vladnil

    vladnil MDL Senior Member

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    I timed the time when the vaccination was done. The countdown has begun. When you are not on the forum for a long time, we will remove you from the list. (English humor)
     
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  15. gorski

    gorski MDL Guru

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    Heart-warming...
     
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  16. Mr.X

    Mr.X MDL Guru

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    #2076 Mr.X, Feb 21, 2021
    Last edited: Feb 21, 2021
    Vaccine finally made you of few words. No verborrhea anymore. Starting to love vaccines...
     
  17. Mr.X

    Mr.X MDL Guru

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    @gorski I really hope you listen Mark Zuckerberg I really do :p

     
  18. vladnil

    vladnil MDL Senior Member

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    If Zuckerberg had said directly that after the vaccine, half of the people on the planet would remain on the planet and do not get vaccinated, it would not solve anything!
    Decide how the whole concert will end Klaus Schwab, Prince of Wales (Prince Charles) Rothschild, etc.
     
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  19. gorski

    gorski MDL Guru

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    What's the big problem - everyone should be cautious with new stuff...

    But he is wrong in his presumptions... Yen? ;)
     
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  20. case-sensitive

    case-sensitive MDL Expert

    Nov 7, 2013
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    >But he is wrong in his presumptions... Yen?

    You hyjjack a whole thread and post one post after another dissing Yen ........ and telling us he hasnt got any idea of what hes talking about ....... and now you dont understand something ...... you ask him for his opinion !!! :)