Coronavirus | Discussion

Discussion in 'Serious Discussion' started by Deleted member 1254778, Feb 28, 2020.

  1. Palladin

    Palladin MDL Senior Member

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    From February 15 2017 published by the Journal of Antibiotics.
    And the MSM is ignoring this?

    Oh, I know why. Covid-19 wasn't specifically mentioned. /s

    https://www.nature.com/articles/ja201711.pdf

    .
     
  2. Mr.X

    Mr.X MDL Guru

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  3. vladnil

    vladnil MDL Senior Member

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    #3323 vladnil, Oct 4, 2021
    Last edited: Oct 4, 2021
    243979059_362353655675536_8316036765386049664_n.jpg 243660722_362353689008866_5380578951800550942_n.jpg 243552337_362353732342195_264351045495659661_n.jpg

    An official request was submitted to the Spanish Ministry of Health on July 22, 2021
    № 001-059144
    Question:
    "Do you have an isolated strain of the coronovirus-SARS-CoV-2-for which vaccines and tests are mass-produced in Spain? Do you know in which countries and laboratories this virus has already been isolated?"
    Response:
    "The Department of Health has no-SARS-CoV-2 virus isolated-and no registry of laboratories where it has already been isolated."
    P/s If the virus has not been isolated in Spain and other countries, what is in the vials that people are injected with en masse? And what are the tests based on? The virus never existed!

    Biden sued by Air Force officers who compare vaccine rule to death sentence

    https://arstechnica.com/tech-policy...s-who-compare-vaccine-rule-to-death-sentence/
     
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  4. Yen

    Yen Admin
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    #3324 Yen, Oct 4, 2021
    Last edited: Nov 11, 2021
    Guess why I always get upset when I hear people saying IVM does not work / cannot work against SARS-COV-2

    I knew this already since last fall 2020
    And I know and understand all details...
    It is unbelievable how much destructive power and irrationality is used to try to 'kill' IVM.

    Like:" What? You are taking a horse dewormer to fight COVID? Are you nuts???".
    To 'be' reasonable one has to take experimental gene based vaccines which are considered to be safe and not that dangerous as 'horse' medicine.
    THIS is sold as rationality and 'truth'!!!

    OK, the 5 MOAs (to have them mechanisms of action here at MDL as well).
    Simple terms and one source at least.
    Added more sources 11/11/2021

    1
    At infection SARS-COV-2 binds with its spike to the human ACE2 receptor.
    IVM binds to the spike and ACE2. By that it sits in between and can inhibit the infection.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7652439/
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/

    2
    Disrupts RdRp an enzyme needed for viral RNA replication. As being said earlier.
    https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full
    https://www.researchsquare.com/article/rs-73308/v1

    3
    Disrupts another enzyme which is called 3-chymotrypsin like protease (3CLPro). Is pivotal for viral replication.
    There are certain enzymes which are responsible to translate certain areas of viral RNA
    Info: https://www.nature.com/articles/s42003-020-01577-x
    https://pubs.rsc.org/en/content/articlehtml/2021/cp/d1cp02967c
    https://pubs.acs.org/doi/abs/10.1021/acsptsci.0c00108#

    4
    Disrupts viral cargo to the cell nucleus. The transporter are Importin alpha/beta.
    Usually when a human cell recognizes a stressor it creates substances (for instance IFN-alpha and Tumor necrosis factor TNF) in order to increase defenses for the nucleus and markers to the neighbor cells to alarm them as well.

    SARS-CoV-2 now uses these transporters Importin alpha/beta to send a message to the nucleus making the defenses staying low and preventing the warning to the neighbor cells.
    IVM blocks the message from being attached to the transporters Importin alpha/beta. So there is no delivery to the nucleus..
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327999/

    This is also mentioned at the article posted by Pallandin above. It's been found at HIV and dengue before, but since SARS-COV-2 uses these transporters as well, it's an MOA against it, too.

    5
    And finally it disrupts NF-κB pathway. This means is anti-inflammatory and reduces the risk for a cytokine storm to occur.
    Why it matters: https://www.frontiersin.org/articles/10.3389/fimmu.2020.598444/full
    And why it can: https://pubmed.ncbi.nlm.nih.gov/19453757/

    General docking study: https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full

    The 'game changer' for 1.2 Billion Molnupiravir from Merck has only one similar MOA to 2.
    A joke.
     
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  5. Palladin

    Palladin MDL Senior Member

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  6. Mr.X

    Mr.X MDL Guru

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  7. R29k

    R29k MDL GLaDOS

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    #3327 R29k, Oct 6, 2021
    Last edited: Oct 6, 2021
    Meanwhile in bikini bottom, spongebob and friends are overdosing.

    https://news.yahoo.com/ivermectin-calls-poison-control-centers-004841746.html

    @Yen i was reading this article and it made this statement ...
    ... Is that true? If it is, what's the difference, just dosage or different structure?
     
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  8. Palladin

    Palladin MDL Senior Member

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    The answer is...Kinda.
    bottom line is that 1% Ivermectin for a horse is the same as 1% solution for humans. There is however paste, and some other external animal products that you might want to stay away from. They state the obvious that the medication is for a horse and that dosage will be different that for a human. Duh!

    Now what they don't say is what's the correct dosage for humans. They only say that you can overdose. It's like saying taking too much Vitamin D will kill you, and if you took 200 2,000mg pills it would probably kill you. But whenever they mention dosage of Vitamin D, they always mention what the average dosage should be, or at least a range.

    Notice when they try to say Ivermectin is bad for you they always qualify it with plenty of, "could cause" and then a list of things that could be caused by taking Ivermectin. Yet they never say, "will cause", only "could cause" to gen up fear.

    Attached is something Yen came up with when I was first asking what the correct dosage should be and how to convert pill dosage, measured in grams to be converted to liquid measured in CC's.

    Attached is the edited version of what he told me to do, along with a simple chart the MSM will never show you that shows the correct dosage of the liquid 1% solution in CC's dosage in relation to weight.

    If the MSM was so concerned with you health they would publish this simple chart to prevent the overdoses they are so worried about.

    The MSM would never link to this explanation of how to go about taking Ivermectin safely:
    https://www.barnhardt.biz/ivermectin/

    .
     

    Attached Files:

  9. vladnil

    vladnil MDL Senior Member

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  10. Yen

    Yen Admin
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    #3330 Yen, Oct 6, 2021
    Last edited: Oct 6, 2021
    It's the (galenic) formulation that is different.
    The science behind it is galenics.

    1)
    There is the active drug IVM.
    There is no other active drug inside. This means the structural formula is exactly the same.
    The pure drug has to follow specifications, especially concerning impurities. There is for instance the USP standard (US Pharmacopoeia).
    It could be (if at all) that IVM for animal administration is allowed to have a bit more of impurities.
    But this usually does not apply to the formulation: injection solution. Here's the highest quality used.

    2)
    The pharmaceutical additives.
    Depending on which galenic formulation you have several pharmaceutical additives.
    Those have a purpose as well, a galenic purpose.
    For instance to press the drug into a pill you cannot just press the drug alone. It would be either an inappropriate amount (either too low or too high) or a bad physical behavior (the pressed stuff just brittles again)...

    At solutions just as injection solutions you have to specify the solvent. If it is not saline, you have to check what it is and how it's to human body.
    I did that (propylene glycol, glycerol formal.) Both substances are harmless to human body, although this combination is mainly used at veterinary meds.

    The issue with veterinary IVM is the correct dose. A horse has another body weight than a human.
    I also posted a disclaimer because I know that when I 'advocate' IVM some might use the veterinary stuff and might calculate the wrong amount (over-dosage).
    Actually there is no issue taking veterinary products.


    Thanks for this.
    But what is more concerning to me is that bit:

    "In summary, our results reveal that selection pressure in a highly vaccinated community (>71% fully vaccinated as of early August 2021) favors more infectious, antibody-resistant VOCs such as the gamma12,32 and delta12,13,21,25 variants, and that high-titer symptomatic post-vaccination infections may be a contributor to viral spread. Concerns have also been raised regarding waning immunity resulting in decreased effectiveness of the vaccine in preventing symptomatic infection over time33. Combined with other potential factors such as relaxation of COVID-19 restrictions and complacency due to “pandemic fatigue”, these data may explain the recent steep rise in COVID-19 cases in San Francisco County (Figure 1)34 and nationwide18 in July-August 2021. Targeted booster vaccinations for vulnerable populations35, potentially guided by monitoring of immune correlates of vaccine efficacy30, will likely be needed in the near future to control viral spread in the community."

    I always said a mass vaccination approach makes no sense. (Can turn out as a backfire).
    Especially to vaccinate 'into' an ongoing pandemic can tun out as a boomerang...

    What many people do not understand.
    In vaccinated people there is a selection pressure, because the vaccines make a certain static antigen. It is still the Wuhan S protein. And we know vaccinated people do infect others. They are leaky (non-sterilizing) vaccines!

    The more the virus mutates there, the farther away from the vaccines the mutations will be. And by that the chance to escape, because the efficacy diminishes by the amount of variation.

    The unvaxxed don't have a pre-immunity based on a particular strain / Wuhan and so they have no selection to a particular variant. Their 'naive' immune system kills any strain with the same affinity.

    This posted article goes into that direction. The first time.
    If it turns out that way, we will experience that the mass vaccination turns things even worse...means the VOC's are favored in the vaxxed and by that keep the pandemic moving on....a sort of cat and mouse game....(where you have to adjust the vaccines again and again without really getting long lasting natural immunity).

    It will result in a high infection plateau (it never gets really down).....it stays there with minor changes....Israel and nations with high vaccination rates should be first showing that...

    Guess why we never vaccinate into a flu season and do the jabs before an upcoming season to have a 'wave-breaker' so a flu epidemic actually never can occur?

    Hmm..always willing to say....the basics of epidemiology cannot be bent.
     
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  11. vladnil

    vladnil MDL Senior Member

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    #3331 vladnil, Oct 6, 2021
    Last edited: Oct 6, 2021
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  12. gorski

    gorski MDL Guru

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    AHAHAHAHAHAAAAAAAAAAAAAA!!!!!!!!!!!!!!!!!!!!!!! WHAT A TWAT!!!!!!!!!!!!!!!!!!!!!!!! :D :D :D :D
     
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  13. vladnil

    vladnil MDL Senior Member

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  14. gorski

    gorski MDL Guru

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  15. gorski

    gorski MDL Guru

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    [​IMG]
     
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  16. gorski

    gorski MDL Guru

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  17. gorski

    gorski MDL Guru

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    Follow the money:
     
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  18. gorski

    gorski MDL Guru

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  19. Mr.X

    Mr.X MDL Guru

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    #3339 Mr.X, Oct 7, 2021
    Last edited: Nov 13, 2021
    Post-vaccination nephrotic syndrome due to Minimal Change Disease

    I share the link to a case report that was published in the American Journal of Kidney Disease: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8028833/ . The article documents a case of a disease known as "Minimal Change Disease (NDE)", which is an affectation of the kidneys that can be severe and is the main cause of nephrosis (kidney damage) in children.

    The clinical report consists of the case of a 50-year-old healthy man (without comorbidities) who 10 days after receiving the SARS-CoV-2 vaccine experienced acute kidney damage and nephrotic syndrome. The clinical signs of him had started within four days of the first dose of the Pfizer vaccine, and included edema (accumulation of fluid) in the legs, hands, abdominal wall and penis. He had altered some blood and clinical parameters that were indicative of severe kidney damage. His kidney function continued to deteriorate and he had to be treated with corticosteroids and hospitalized for 10 days. The clinical picture has been described in other conditions, including the reception of some vaccines, such as Influenza. Although the authors acknowledge that the association between the reception of the SARS-CoV-2 vaccine and the occurrence of NDE kidney damage, they indicate that it is the first case and that they should wait for more reports to know the true incidence of this "possible adverse effect of the vaccine ". The interesting thing is that this study was published in April 2021, and since then more reports have indeed been reported, 14 in fact, and associated with the Pfizer, Astrazeneca, Johnson & Johnson and Moderna vaccines. I also share the links to these articles:
    https://pubmed.ncbi.nlm.nih.gov/34143368/
    https://pubmed.ncbi.nlm.nih.gov/34119510/
    https://pubmed.ncbi.nlm.nih.gov/34181144/
    https://pubmed.ncbi.nlm.nih.gov/34000278/
    https://pubmed.ncbi.nlm.nih.gov/34242687/
    https://pubmed.ncbi.nlm.nih.gov/34119512/
    https://pubmed.ncbi.nlm.nih.gov/34023417/
    https://pubmed.ncbi.nlm.nih.gov/34048824/
    https://pubmed.ncbi.nlm.nih.gov/33992727/
    https://pubmed.ncbi.nlm.nih.gov/33839200/
    https://pubmed.ncbi.nlm.nih.gov/34052236/
    https://pubmed.ncbi.nlm.nih.gov/33964312/
    https://pubmed.ncbi.nlm.nih.gov/34342187/
    https://pubmed.ncbi.nlm.nih.gov/34337193/

    Due to the seriousness that nephrotic syndrome and acute renal failure can have, it is important and necessary for doctors to be aware of these adverse effects in order to be able to recognize the symptoms in a timely manner in vaccinated patients, as well as to have more elements to recommend, based on the patient's medical history, the decision that is best for the integrity, safety and well-being of the patient as to whether or not to receive the vaccination.

    I hope you find this information useful and pass it on to your medical acquaintances as well as loved ones with kidney problems, who may be more susceptible to this adverse effect.

    I send you greetings, Karina AW

    https://t.me/akashacomunidad/603
     
  20. Mr.X

    Mr.X MDL Guru

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