Coronavirus | Discussion

The latest Pfizer Data Dump for July is available for download.

Fortunately they have zipped up all the files by month so you can download just the 13 documents and browse at your leisure instead of having to download 363 of them one at a time.

https://phmpt.org/multiple-file-downloads/

Note: Some of the files have an .XPT extension and that is a data file from SAS.
SAS Institute provides a nice tool, the SAS Universal Viewer, for exactly this purpose.
To download this free software, go to https://support.sas.com/downloads/package.htm?pid=2491

Unless you have an SAS account you will be prompted to create a user/password to access the file but it is a simple process and they will ask for you email address and then they will send a confirmation email to create your user/password. Then download and install the SAS Universal Viewer.

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Guillain-Barré Syndrome and COVID-19 Vaccines

43 scientific papers...

1. GM1 ganglioside antibody and COVID-19-related Guillain Barre syndrome: case report, systemic review, and implications for vaccine development: https:// www.sciencedirect.com/science/article/pii/S2666354621000065
2. Guillain-Barré syndrome after AstraZeneca COVID-19 vaccination: causal or casual association: https://www.sciencedirect.com/science/article/pii/S0303846721004169
3. Sensory Guillain-Barré syndrome after ChAdOx1 nCov-19 vaccine: report of two cases and review of the literature: https://www.sciencedirect.com/science/article/pii/S0165572821002186
4. Guillain-Barré syndrome after the first dose of SARS-CoV-2 vaccine: a temporary occurrence, not a causal association: https://www.sciencedirect.com/science/article/pii/S2214250921000998.
5. Guillain-Barré syndrome presenting as facial diplegia after vaccination with COVID-19: a case report: https://www.sciencedirect.com/science/article/pii/S0736467921006442
6. Guillain-Barré syndrome after the first injection of ChAdOx1 nCoV-19 vaccine: first report: https://www.sciencedirect.com/science/article/pii/S0035378721005853.
7. SARS-CoV-2 vaccines are not safe for those with Guillain-Barre syndrome following vaccination: https://www.sciencedirect.com/science/article/pii/S2049080121005343
8. Guillian Barré syndrome after vaccination with mRNA-1273 against COVID-19:
https://pubmed.ncbi.nlm.nih.gov/34477091/
9. A novel case of bifacial diplegia variant of Guillain-Barré syndrome after vaccination with Janssen COVID-19: https://pubmed.ncbi.nlm.nih.gov/34449715/
10. Sensory Guillain-Barré syndrome following ChAdOx1 nCov-19 vaccine: report of two cases and review of the literature: https://pubmed.ncbi.nlm.nih.gov/34416410/.
11. Facial diplegia: a rare and atypical variant of Guillain-Barré syndrome and the Ad26.COV2.S vaccine: https://pubmed.ncbi.nlm.nih.gov/34447646/
12. Guillain-Barré syndrome after ChAdOx1 nCoV-19 COVID-19 vaccination: a case series: https://pubmed.ncbi.nlm.nih.gov/34548920/
13. AstraZeneca COVID-19 vaccine and Guillain-Barré syndrome in Tasmania: a causal link: https://pubmed.ncbi.nlm.nih.gov/34560365/
14. COVID-19, Guillain-Barré and vaccineA dangerous mix: https://pubmed.ncbi.nlm.nih.gov/34108736/.
15. Guillain-Barré syndrome after the first dose of Pfizer-BioNTech COVID-19 vaccine: case report and review of reported cases: https://pubmed.ncbi.nlm.nih.gov/34796417/
16. Guillain-Barre syndrome after BNT162b2 COVID-19 vaccine: https://link.springer.com/article/10.1007/s10072-021-05523-5.
17. COVID-19 adenovirus vaccines and Guillain-Barré syndrome with facial palsy: https://onlinelibrary.wiley.com/doi/10.1002/ana.26258.
18. Association of receipt association of Ad26.COV2.S COVID-19 vaccine with presumed Guillain-Barre syndrome, February-July 2021: https://jamanetwork.com/journals/jama/fullarticle/2785009
19. A case of Guillain-Barré syndrome after Pfizer COVID-19 vaccine: https://pubmed.ncbi.nlm.nih.gov/34567447/
20. Guillain-Barré syndrome associated with COVID-19 vaccination: https://pubmed.ncbi.nlm.nih.gov/34648420/.
21. Rate of recurrent Guillain-Barré syndrome after COVID-19 BNT162b2 mRNA vaccine: https://jamanetwork.com/journals/jamaneurology/fullarticle/2783708
22. Guillain-Barre syndrome after COVID-19 vaccination in an adolescent: https://www.pedneur.com/article/S0887-8994(21)00221-6/fulltext.
23. Guillain-Barre syndrome after ChAdOx1-S / nCoV-19 vaccination: https://pubmed.ncbi.nlm.nih.gov/34114256/.
24. Guillain-Barre syndrome after COVID-19 mRNA-1273 vaccine: case report: https://pubmed.ncbi.nlm.nih.gov/34767184/
25. Guillain-Barre syndrome following SARS-CoV-2 vaccination in 19 patients: https://pubmed.ncbi.nlm.nih.gov/34644738/.
26. Guillain-Barre syndrome presenting with facial diplegia following vaccination with COVID-19 in two patients: https://pubmed.ncbi.nlm.nih.gov/34649856/
27. A rare case of Guillain-Barré syndrome after COVID-19 vaccination: https://pubmed.ncbi.nlm.nih.gov/34671572/
28. Neurological complications of COVID-19: Guillain-Barre syndrome after Pfizer COVID-19 vaccine: https://pubmed.ncbi.nlm.nih.gov/33758714/
29. COVID-19 vaccine causing Guillain-Barre syndrome, an uncommon potential side effect: https://pubmed.ncbi.nlm.nih.gov/34484780/
30. Guillain-Barre syndrome after the first dose of COVID-19 vaccination: case report; https://pubmed.ncbi.nlm.nih.gov/34779385/.
31. Guillain-Barre syndrome after the first injection of ChAdOx1 nCoV-19 vaccine: first report: https://pubmed.ncbi.nlm.nih.gov/34217513/.
32. A case of sensory ataxic Guillain-Barre syndrome with immunoglobulin G anti-GM1 antibodies after first dose of COVID-19 BNT162b2 mRNA vaccine (Pfizer): https://pubmed.ncbi.nlm.nih.gov/34871447/
33. A variant of Guillain-Barré syndrome after SARS-CoV-2 vaccination: AMSAN: https://pubmed.ncbi.nlm.nih.gov/34370408/.
34. A rare variant of Guillain-Barré syndrome after vaccination with Ad26.COV2.S: https://pubmed.ncbi.nlm.nih.gov/34703690/.
35. Guillain-Barré syndrome after SARS-CoV-2 vaccination in a patient with previous vaccine-associated Guillain-Barré syndrome: https://pubmed.ncbi.nlm.nih.gov/34810163/
36. Guillain-Barré syndrome in an Australian state using mRNA and adenovirus-vector SARS-CoV-2 vaccines: https://onlinelibrary.wiley.com/doi/10.1002/ana.26218
37. Variant Guillain-Barré syndrome occurring after SARS-CoV-2 vaccination: https://pubmed.ncbi.nlm.nih.gov/34114269/
38. Guillian-Barre syndrome with axonal variant temporally associated with Modern SARS-CoV-2 mRNA-based vaccine: https://pubmed.ncbi.nlm.nih.gov/34722067/
39. Guillain-Barre syndrome after the first dose of SARS-CoV-2 vaccine: a temporary occurrence, not a causal association: https://pubmed.ncbi.nlm.nih.gov/33968610/
40. SARS-CoV-2 vaccines can be complicated not only by Guillain-Barré syndrome but also by distal small fiber neuropathy: https://pubmed.ncbi.nlm.nih.gov/34525410/
41. Clinical variant of Guillain-Barré syndrome with prominent facial diplegia after AstraZeneca 2019 coronavirus disease vaccine: https://pubmed.ncbi.nlm.nih.gov/34808658/
42. Miller-Fisher syndrome and Guillain-Barré syndrome overlap syndrome in a patient after Oxford-AstraZeneca SARS-CoV-2 vaccination: https://pubmed.ncbi.nlm.nih.gov/34848426/
43. Bilateral facial weakness with a variant of paresthesia of Guillain-Barre syndrome after Vaxzevria COVID-19 vaccine: https://pubmed.ncbi.nlm.nih.gov/34261746/

 

@Yen - new variant from India is already in the UK... Any insights, please?

Infections are through the roof, hospitalisations are on the rise again, apparently many people are still getting long C-19 etc. etc.

 

Intermittent fasting and immunomodulation

Dear Akasha Community Members:

Honestly, I don't know how many times I have explained that the disease known as COVID-19 is not really a 'respiratory problem' in its origin (as, for example, the Influenza would be), but a problem of exacerbated inflammation caused by poor immunomodulation in response to components of the virus associated with the disease, including the Spike protein.

After I explained it in March 2021 to a group of medical students from the Montemayor University during a class that I gave by invitation, and which was recorded and uploaded to YouTube (I called my class 'The other side of the coin' , and that you can see at: https://odysee.com/@AkashaComunidad...se.--La-otra-cara-de-la-moneda-.-Abril-2021:b ), some colleagues and human doctors were outraged and others called me a liar. How dare a veterinarian say that COVID-19 was not due to pneumonia caused by viral replication and, furthermore, indicate that treating him with mechanical ventilators after intubating them was a way of causing barotrauma and increasing the risk of dying from the patient? If that was the medical protocol they were told to use! The point is that his indignation did not take away, nor does it take away from the fact that once the pathogenesis is understood, that is, the mechanisms and events that explain the disease, the appropriate treatment becomes logical, and it also works: more than give them paracetamol, send them home, wait for their oxygenation to drop and then intubate them (9/10 died intubated in 2020), it was necessary to stop this severe inflammation, help destroy the clots that had formed in the endothelium of the vessels blood cells and help modulate immune responses. These treatments, developed by questioning and not only obedient doctors, such as Dr. Zelenko, several doctors from America's Frontline Doctors, from Doctors for Truth, from COMUSAV, etc., understood this and adjusted their protocols so that a correct immunomodulation was achieved. . There are many protocols, and it is not that a single product or drug is a 'panacea'. If what we want is to immunomodulate, then there are many ways to achieve it.

Today I am sharing this study, by Horne and colleagues, titled "Association of Intermittent Fasting with Less Severity of COVID-19 in the Pre-SARS-CoV-2 Vaccine Era: An Observational Cohort from the INSPIRE Registry" which has just been published in BMJ Nutrition, Prevention and Health (https://nutrition.bmj.com/content/early/2022/06/30/bmjnph-2022-000462)

In that study, they examined the effect of intermittent fasting on the severity of COVID-19 and SARS-CoV-2 infection. They found a significant decrease (Hazard Ratio: 0.63) in study participants who practiced intermittent fasting. The risk of infecting did not change. That is, although they were infected with the same risk, the severity and mortality was noticeably lower in those who practiced intermittent fasting. The study was done during 2020 and the first part of 2021, before the inoculations, when the Delta variant was circulating (that is, when the virulence of that virus was still a little higher).

And why did intermittent fasting reduce the severity of symptoms? Because, as I mentioned before, the symptoms are due to immune dysregulation that leads to exaggerated inflammation, and intermittent fasting is a way to immunomodulate.

This is achieved by:

1) induce gluconeogenesis and activate ketogenesis, which increases the amount of fatty acids (such as linoleic acid)
2) increased production of galectin 3, which modulates inflammation.

Both mechanisms help to modulate the immune system, and linoleic acid also 'sticks' to the Spike protein and reduces its interaction with ACE2 (remember that this interaction initiates a cascade of events that culminates in endothelial damage, dysregulation of the renin angiotensin axis, and severe inflammation).

You can consult the references on these points in the study that I shared with you.

I imagine the directors and shareholders of pharmaceutical companies and medical associations furious, out of their minds. Fast? - they will ask breathlessly, that is, it is no longer just a question of having to speak pests against a cheap drug that no longer has a patent, such as Ivermectin, and give indications to the media that they refer to it as 'medicine for horses', Not to mention the many studies that have shown that it works; It is no longer a question of ignoring a simple and cheap product like amantadine from the anti-flu medicine, of demonizing a chemical substance like ClO₂ despite the fact that its proper use has not been associated, in FAERS or in other registration systems, with a danger sign. Now do you find evidence that intermittent fasting (something that costs nothing, that requires nothing, reduces the severity of the COVID picture, and also implies that it can be useful for many other conditions associated with severe inflammation? can! - some will even have tears in their eyes. I almost feel sorry for their grief. Almost, but no. Because, unfortunately, it is predictable that they will start (if they haven't already) to spread news about the 'damages that could be caused by the intermittent fasting.” Could it be that some sudden deaths of young people will even be attributed to it?

So, finally, as for everything I share, I recommend that you read, investigate, ponder. It is not about following a particular recipe as if it were a 'panacea', it is about understanding that there are many real options to stay healthy.

Have a nice day, Karina AW

https://t.me/akashacomunidad/1596

 

New variant is insanely contagious. No idea where it started but it looks like anyone I had any contact with over the last week or so also has it.

I am now on team double/double. 2 shots and 2 infections (at least that I know of, likely more than that).

 

OK, I haven't read it all yet but I will post it here, just in case, on the off chance some people might be interested... As you said, we urgently need long Covid meds/strategy...

Mayo Clinic: "Research suggests that (..) 1 in 5 people ages 18 to 64 has at least one medical condition that might be due to COVID-19.
https://www.mayoclinic.org/diseases...th/coronavirus-long-term-effects/art-20490351

For instance, my lung capacity is down and I have occasional bouts of breathing problems, stuff in my wind-pipe etc. It's similar to asthma but asthma behaves differently, it comes and goes, when it comes you must use your inhalers for a while, then you're free for a long time (I do, anyhow). This is different, it's constantly here, in the background, menacing...

"CDC: 13.3% at one month or longer after infection 2.5% at three months or longer, based on self-reporting More than 30% at 6 months among patients who were hospitalized"

https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html

"Nature. They put it at 7% so that is a very different percentage. Still concerning for anyone TRULY concerned about economy. let alone people's quality of life:"

https://www.nature.com/articles/d41586-022-01453-0

"Johns Hopkins has an article on it but does not list how many peopple get it. We are of course, learning as we go..."

https://www.hopkinsmedicine.org/hea...vid-long-haulers-long-term-effects-of-covid19

"Apart from 'long covid' there are some dire chances of getting this stuff, that anyone organising a society should be thinking about..."

https://medicalxpress.com/news/2022-06-covid-positive-patients-higher-neurodegenerative.html

"COVID-19 positive patients at higher risk of developing neurodegenerative disorders, new study shows
by The European Academy of Neurology


Credit: Unsplash/CC0 Public Domain
COVID-19 positive outpatients are at an increased risk of neurodegenerative disorders compared with individuals who tested negative for the virus, a new study presented today at the 8th European Academy of Neurology (EAN) Congress has shown.

The study, which analyzed the health records of over half of the Danish population, found that those who had tested positive for COVID-19 were at an increased risk of Alzheimer's disease, Parkinson's disease, and ischemic stroke.

Out of the 919,731 individuals that tested for COVID-19 within the study, researchers found that the 43,375 people who tested positive had a 3.5 times increased risk of being diagnosed with Alzheimer's disease, 2.6 times with Parkinson's disease, 2.7 times with ischemic stroke and a 4.8 times increased with intracerebral hemorrhage (bleeding in the brain). While neuroinflammation may contribute to an accelerated development of neurodegenerative disorders, the authors also highlighted implications of the scientific focus on long-term sequelae after COVID-19.

The study analyzed in- and outpatients in Denmark between February 2020 and November 2021, as well as influenza patients from the corresponding pre-pandemic period. Researchers used statistical techniques to calculate relative risk, and results were stratified for hospitalization status, age, sex, and comorbidities.

Dr. Pardis Zarifkar, lead author from the Department of Neurology, Rigshospitalet, Copenhagen, Denmark, explained, "More than two years after the onset of the COVID-19 pandemic, the precise nature and evolution of the effects of COVID-19 on neurological disorders remained uncharacterized. Previous studies have established an association with neurological syndromes, but until now it is unknown whether COVID-19 also influences the incidence of specific neurological diseases and whether it differs from other respiratory infections."

The increased risk of most neurological diseases was, however, no higher in COVID-19 positive patients than in people who had been diagnosed with influenza or other respiratory illnesses. COVID-19 patients did have a 1.7 times increased risk of ischaemic stroke in comparison to influenza and bacterial pneumonia inpatients over 80 years of age.

The frequency of other neurodegenerative illnesses such as multiple sclerosis, myasthenia gravis, Guillain-Barré syndrome and narcolepsy did not increase after COVID-19, influenza, or pneumonia.

Dr. Pardis Zarifkar added, "We found support for an increased risk of being diagnosed with neurodegenerative and cerebrovascular disorders in COVID-19 positive compared to COVID-negative patients, which must be confirmed or refuted by large registry studies in the near future. Reassuringly, apart [from] ischemic stroke, most neurological disorders do not appear to be more frequent after COVID-19 than after influenza or community-acquired bacterial pneumonia."

"These findings will help to inform our understanding of the long-term effect of COVID-19 on the body and the role that infections play in neurodegenerative diseases and stroke.""

 

Continuation of the above post:

"Out of the 919,731 individuals that tested for COVID-19 within the study, researchers found that the 43,375 people who tested positive had a 3.5 times increased risk of being diagnosed with Alzheimer's disease, 2.6 times with Parkinson's disease, 2.7 times with ischemic stroke and a 4.8 times increased with intracerebral haemorrhage (bleeding in the brain)."

"T-cell depletion.. (Covid wrecks your immune system. After covid, the 'normal flu' is worse. An Adenovirus might cause liverfailure all of a sudden... in short, Covid might lead to Auto Immune Deficiency Syndrome)..."

https://www.frontiersin.org/articles/10.3389/fimmu.2020.600405/full

"Aberrant T cell differentiation and lymphopenia are hallmarks of severe COVID-19 disease. Since T cells must race to cull infected cells, they are quick to differentiate and achieve cytotoxic function. With this responsiveness, comes hastened apoptosis, due to a coupled mechanism of death and differentiation in both CD4+ and CD8+ lymphocytes via CD95 (Fas) and serine-threonine kinase (Akt). T cell lymphopenia in severe cases may represent cell death or peripheral migration. These facets depict SARS-Cov-2 as a lympho-manipulative pathogen; it distorts T cell function, numbers, and death, and creates a dysfunctional immune response. Whether preservation of T cells, prevention of their aberrant differentiation, and expansion of their population may alter disease course is unknown. Its investigation requires experimental interrogation of the linked differentiation and death pathway by agents known to uncouple T cell proliferation and differentiation in both CD4+ and CD8+ T cells."

20% = 1in5!!!

https://missoulian.com/news/local/m...twpB6aZLvkoTOAjktACIFsKHhFmqJeHxOpcmyNk9QHs3g

washingtonpost.com
Vaccines may not prevent many symptoms of long covid, study suggests

Veterans Affairs analyzed records from nearly 34,000 people in the United States who experienced breakthrough infections.

"The ME community was on it early."

https://www.infectioncontroltoday.com/view/getting-a-head-start-on-treating-long-covid

"It might cripple the country in no time."

https://www.tandfonline.com/doi/full/10.1080/13504851.2022.2098239#.Ys_Opc9WPgI.twitter

ABSTRACT

"COVID-19 is more likely to lead to Long COVID among persons of working age. We outline the first estimates of the impact of Long Covid on employment in the UK. Using estimates of cumulative prevalence of Long COVID, activity-limiting Long COVID in the working-age population and of economic inactivity and job loss resulting from Long COVID, we provide evidence of the profound impact of Long COVID on national labour supply. Since the start of the pandemic, cumulatively 2.9 million people of working age (7% of the total) in the UK have had, or still have, Long COVID. This figure will continue to rise due to very high infection rates in the Omicron wave. Since the beginning of the pandemic, economic inactivity due to long-term sickness has risen by 120,900 among the working-age population, fuelling the UK’s current labour shortage. An estimated 80,000 people have left employment due to Long COVID. We argue that governments need to tackle the twin challenges to public health and labour supply and provide employment protection and financial support for individuals and firms affected by Long COVID."

At the moment the mayhem in the economy is a mixed bag, social and medical issues but if it continues unabated...

Oh, dear... A "non-existant" so called pandemic, eh...

 

Good grief!
If it wasn't for they insist it is the disease, I'd think they were talking about the nefarious jabs.
Hmm, having second thoughts, I'm pretty sure the inoculations are the cause.

 

I bet there'll be studies comparing the vaxxed and unvaxxed, partially vaxxed and just sick...

 

Government decision to scrap free lateral flow tests is looking even more reckless


theguardian.com
UK Covid infections soar by almost 30% in a week
Estimated 3.5 million people thought to have disease in first week of July, with Omicron sub-variants blamed

 

Reinvent the wheel

Dear Akasha Community Members:

Sometimes it makes me laugh when something is published that shows what those who know immunology knew, and that the media, many doctors (and some dentists) insisted on declaring that it was not so.

When they began to promote COVID19 inoculations in pregnant and lactating women (despite the evident lack of studies showing their need, effectiveness and long-term risks), one of the most used (and still used) 'justifications' was to promote the use of inoculations, is that they believed and believe that vaccines manage to do what the immune system cannot do. That almost magical thinking demonstrates a marked ignorance about Immunology and how vaccines work (when they do). Its efficacy (when it exists) is based precisely on the fact that the immune system of the vaccinated organism works.

So, the logic of the volunteer-commercial-promoters-or-paid-for-pharmaceuticals was that it was important that pregnant women be inoculated in order to pass the antibodies to their children. 'Even women who have already been infected should do it' they vociferated (and vociferate) intoning each vowel carefully and raising their voice while pointing an accusing finger...

The thing is, no, actually. It is not like this. They are very wrong. If they had reread their Immunology books, or if they had thought without the filter of the bono-pharmaceutical obliterating their neofrontal cortex, they might remember that mucosal and blood antibodies (as well as other immune components) are transmitted by the milk of convalescent women, and that these are generated - after a natural infection - against many and diverse fragments of many and diverse proteins (not only against Spike, as the inoculations of Pfizer, Moderna, AstraZeneca, Johnson & Johnson, Cansino and Novavax do). In other words, the natural immunity passively transmitted from mother to baby through milk and blood is broader, more robust, and protects against many more different parts of the virus (making it more efficient, even if there are some proteins... like Spike... that mutate a lot when the virus replicates), than the antibodies that are transmitted through milk and blood to the baby by an inoculated woman. And furthermore, this is achieved by a previously infected woman, without having the risk of an adverse reaction to her and the baby due to the possibility of transmission of the adenoviral vector or the mRNA or the nanolipids contained in the inoculations.

So, in the publication by Wang et al., in the journal Vaccines, they found that - as anyone who knows Immunology would know - IgG and IgA antibodies are more durable and diverse (not just against Spike) in the blood and breast milk of convalescent women than in pregnant women.

https://www.mdpi.com/2076-393X/10/6/980

Oh, oh, oh... I'm glad they published it, but seeing that some reinvent the wheel becomes tiresome at times.

I invite you to see it, analyze what they did, analyze the results, the figures, and come to your own conclusions.

I greet you and I wish you a nice afternoon/evening, Karina AW

https://t.me/akashacomunidad/1610

 

What kind of immunology?
Who knows about it?
Do medics not know why some people are Rh positive and others are negative? (It's a mystery to them).
Do medics not know why people have a body temperature of 36.6 degrees most of the time?

 

@Yen, who knows what you're talking about is of fundamental importance

 

I'd still rather not get ill...

 

Here's a very good discussion regarding Covid-19 by Russell L. Blaylock posted on https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/

It's a long read for sure, but well worth it, with links to original documents referenced in the article.

There's also a pdf of it available, without all the web junk in it.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9062939/pdf/SNI-13-167.pdf