Coronavirus | Discussion

Discussion in 'Serious Discussion' started by Deleted member 1254778, Feb 28, 2020.

  1. Michaela Joy

    Michaela Joy MDL Crazy Lady

    Jul 26, 2012
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    Tell that to my friend who managed to survive COVID 19.
     
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  2. WindowsGeek

    WindowsGeek MDL Expert

    Jun 30, 2015
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  3. Bat.1

    Bat.1 MDL Expert

    Oct 18, 2014
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    De one Bat going to if him gets kung flu :roflmao:
     
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  4. MS_User

    MS_User MDL Guru

    Nov 30, 2014
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    guy stop smoking crack;)
     
  5. zen45

    zen45 MDL Addicted

    Feb 25, 2010
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    to all the people that died and all the people in the hospitals, to all the health care workers that died , please raise your hand if you believe this virus isn't real and its a government conspiracy hmmmm nobody ??
     
  6. vladnil

    vladnil MDL Senior Member

    Jan 19, 2019
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    https://www.euromomo.eu/

    Mortality has always been! You have been deceived, deceived. And you are like blind kittens
     
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  7. gorski

    gorski MDL Guru

    Oct 21, 2009
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    It seems to me Hare has crashed through your eyes at snail's pace and taken all the grey matter along...
     
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  8. Mr.X

    Mr.X MDL Guru

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  9. drew84

    drew84 MDL Expert

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    #549 drew84, May 27, 2020
    Last edited: May 27, 2020
    This is going to cost me...

    COVID-19

    The UK, one of the most actively monitored countries in the world
    Germany, nearest relative - in terms of backckground and National Health Service
    Wuhan - where this all supposedly started

    Wuhan = POP- 11M, 82,993 (infected (whole of CHINA)), 4,634 (Dead (whole of CHINA)),... RECOVERED = 78,280, SERIOUS [CRITICAL] = 5,...

    GDR = POP-84M, 181,770 (infected), 8,526 (Dead)... RECOVERED = 162,800, ACTIVE CASES = 10,444, SERIOUS [CRITICAL] = 821

    UK = POP- 63M, 267,240 (infected), 37,460 (Dead), RECOVERED = N/A, ACTIVE CASES = N/A, SERIOUS [CRITICAL] = 1,559,... <-- Seriously, none of these figures have changed in 2 months +

    Q: what is wrong with this equation (Information)
     
  10. Yen

    Yen Admin
    Staff Member

    May 6, 2007
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    #550 Yen, May 28, 2020
    Last edited: May 28, 2020
    There is something wrong with the UK statistics even at Johns Hopkins map.
    I suppose it is a technical thing.
    United Kingdom
    Confirmed: 268.619
    Deaths: 37.542
    Recovered: 1.166
    Active: 229.911

    The active value is too high and the recovered value too low.
    I guess it's something to do with the fact that recovering is calculated from the infected plus a few weeks. Those then get subtracted as 'recovered' the rest remains as 'active'.

    Besides of that the mortality rate is quite high. (More than double compared to Ireland)

    If you compare that to Ireland:
    Ireland
    Confirmed: 24.803
    Deaths: 1.631
    Recovered: 22.089
    Active: 1.083

    This seems far more reasonable...(Active/recovered/confirmed ratio)
     
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  11. gorski

    gorski MDL Guru

    Oct 21, 2009
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    They drink more in Ireland... :D
     
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  12. Bat.1

    Bat.1 MDL Expert

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    Now Bat pondering if de WHO knew all along dat RIOTING was both a vaccine against and cure for de Kung Flu :g:
     
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  13. gorski

    gorski MDL Guru

    Oct 21, 2009
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    Some scientists think that the vaccine might NOT be the answer to this question.

    They discovered that almost half the population did not develop any antibodies. A case of husband and wife. He got hospitalised, they tested her and she was infected, too but she was asymptomatic, could give it to anyone but did not have antibodies of any kind, just did not react to the virus, was carrying it happily but it did nothing to her...

    We'll see...
     
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  14. zen45

    zen45 MDL Addicted

    Feb 25, 2010
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    perhaps they will never find a vaccine , perhaps they will have a flu type of vaccine , each year they seem to change the flu shot when the flu evolves it doesn't stop the flu it just makes it weaker in your system , people still get sick and die from the flu but not as many before the shots was developed ! hell they haven't even cured the common cold yet !!! and these "experts" are saying we will have a cure by 2021 !!! sure they will ! wanna buy a bridge sell it to you for whole sale LOL
     
  15. Yen

    Yen Admin
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    #555 Yen, Jun 5, 2020
    Last edited: Jun 5, 2020
    The matter is complex.
    There are mutations already. But what impact those mutations will have on the behaviour of the virus is still unknown.
    Some mutations can have an influence on the immune answer of human body.
    And most of mutations that have happened do also vanish again.
    This makes it even harder to make predictions.

    I am no expert, but I know the ACE2-receptor at human cells plays an important role. It is the docking site where SARS-CoV-2 is docking at.

    The matter does not only concern immunity / vaccine it also concerns behaviour such as infectiosity, for instance:
    https://www.biorxiv.org/content/10.1101/2020.04.29.069054v2

    And there will be always certain people with conspicuous medical reports.
    The reasons why can be various.

    Let's hope the lasting signifiant and harmful mutations are slower than the development of medical countermeasures once we have found something.

    It is possible that future vaccines have to be 'updated' such as flu. But nobody can say that today if and when...

    Important is to have different approaches for vaccine development at once.

    Anyway it is a bitter irony. Survival by fitting also applies to the virus even though humans have classified viruses as non living beings.

    Since this applies to humans as well, "corona, SARS-CoV-2" also could become ('degenerate to') a 'harmless common cold' in the future.

    AFAIK there are 4 corona 'common cold viruses' known at humans.They could have been as severe as when they firstly appeared at humans.

    Genetic research suggests one of them got to humans around 1889 already.
     
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  16. gorski

    gorski MDL Guru

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    Easy now, zen, if we are not privvy to all the important info....
     
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  17. gorski

    gorski MDL Guru

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    https://www.sciencedaily.com/releases/2020/05/200514115411.htm

    Twenty-four hours after infection, the virus causes distinct changes to the composition of the host proteome: while cholesterol metabolism is reduced, activities in carbohydrate metabolism and in modification of RNA as protein precursors increase. In line with this, the scientists were successful in stopping virus reproduction in cultivated cells by applying inhibitors of these processes. Similar success was achieved by using a substance that inhibits the production of building blocks for the viral genome.

    The findings have already created a stir on the other side of the Atlantic: in keeping with common practise since the beginning of the corona crisis, the Frankfurt researchers made these findings immediately available on a preprint server and on the website of the Institute for Biochemistry II. Professor Ivan Dikic, Director of the Institute, comments: "Both the culture of 'open science', in which we share our scientific findings as quickly as possible, and the interdisciplinary collaboration between biochemists and virologists contributed to this success. This project started not even three months ago, and has already revealed new therapeutic approaches to COVID-19."

    @Yen... ;)
     
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  18. R29k

    R29k MDL GLaDOS

    Feb 13, 2011
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  19. gorski

    gorski MDL Guru

    Oct 21, 2009
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    Yes, it's not a new point.

    What is new is that about half the population won't react to it in any way whatsoever....
     
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  20. Yen

    Yen Admin
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    #560 Yen, Jun 6, 2020
    Last edited: Jun 6, 2020
    This is interesting, thanks for that.
    Anyway I guess the important part for the readers out there is : How do I classify news about a certain medical research success when I have read certain scientific reports?

    If not impossible at all (even for the experts) we can (we= everybody who has some practical experiences on clinical R&D and states) categorize the subject and the level where they are working at. (Where at the pipeline so to say).

    This here belongs to basic research (finding weak spots at corona reproduction) to narrow down potential drugs that might be suitable for clinical trials. It concerns the very back of the dev pipeline.
    The more in the back the more barriers to break down.

    The in vitro / in vivo barrier to take.....I have seen lots of drugs we've designed failing at our own research. (no corona research).
    The reason for that is simple. The drug has to arrive in vivo there where it has shown its in vitro action. This factor is a big unknown. And on its way it should not interact negatively elsewhere.

    Anyway it is important to have a pipeline that is full. This one can trigger more in vivo studies.

    The front of corona dev pipeline is PHASE II we have now with mRNA-1273

    (And yes we have already one approval, Remdesivir)
     
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