The MDL Times - Science and Tech. News on MDL

Discussion in 'Serious Discussion' started by kldpdas, Jun 30, 2011.

  1. R29k

    R29k MDL GLaDOS

    Feb 13, 2011
    5,171
    4,811
    180
    Phys.org: Scientists announce a breakthrough in determining life's origin on Earth—and maybe Mars.
    https://phys.org/news/2022-06-scientists-breakthrough-life-earthand-mars.html

    Phys.org: Study suggests that most of our evolutionary trees could be wrong.
    https://phys.org/news/2022-06-evolutionary-trees-wrong.html

    Phys.org: Why did Mars dry out? New study points to unusual answers.
    https://phys.org/news/2022-05-mars-unusual.html


    SciTechDaily: Astronomers Discover Mysterious Circular Ring – Likely of Intergalactic Origin.
    https://scitechdaily.com/astronomer...circular-ring-likely-of-intergalactic-origin/

    Phys.org: Chemists synthesize psychotropic compound from rainforest tree.
    https://phys.org/news/2022-05-chemists-psychotropic-compound-rainforest-tree.html

    Science: How life could have arisen on an 'RNA world'.
    https://www.science.org/content/article/how-life-could-have-arisen-rna-world

    Gamesradar: MeetLight could be the perfect combo of Valheim and Stardew Valley.
    https://www.gamesradar.com/meetlight-could-be-the-perfect-combo-of-valheim-and-stardew-valley/

    Space.com: Listen to the 'echoes' of black holes chowing down on stars.
    https://www.space.com/black-hole-echoes-study-sound/

    ScienceAlert: Scientists Follow a 'Yellow Brick Road' in a Never-Before-Seen Spot of The Pacific Ocean.
    https://www.sciencealert.com/scient...a-never-before-seen-spot-of-the-pacific-ocean
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  2. Yen

    Yen Admin
    Staff Member

    May 6, 2007
    13,081
    13,977
    340
    This is very impressing. Success at fighting cancer.
    "Rectal Cancer Disappears After Experimental Use of Immunotherapy"

    Rectal Cancer Disappears After Experimental Use of Immunotherapy | Memorial Sloan Kettering Cancer Center (mskcc.org)

    PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer | NEJM
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  3. zen45

    zen45 MDL Addicted

    Feb 25, 2010
    918
    2,393
    30
    Possibly this will create new inroads into curing other cancer types and get away from radiation and chemotherapy which also harms the body (its like using a shot gun to kill a fly on a fence it destroys the fence but may kill the fly )
     
  4. zen45

    zen45 MDL Addicted

    Feb 25, 2010
    918
    2,393
    30
    Also a cure wont kill the medical professional's cash cow, it will lower their profits for a bit , but people will still get cancer but they will be able to cure it for a higher fee !
     
  5. Yen

    Yen Admin
    Staff Member

    May 6, 2007
    13,081
    13,977
    340
    #1165 Yen, Jun 9, 2022
    Last edited: Jun 9, 2022
    I never saw such a study with 100% efficacy when it comes to cancer.
    Sure they were only 16 people, but the results are outstanding.

    The drug used, dostarlimab, has got full FDA approval last year (August). It is a monoclonal antibody that blocks PD-1 on immune cells. It has only little side effects...

    The financial profits are still high, you can sell it with good margin.

    We should not compare to the therapies used so far which are, as you've mentioned, like dark age measures (to use a gun to kill a fly) in the name of profit only.
    Countless of chemotherapies, radiation and surgery might get more profit at first sight, but probably not long term...(cancer is often fatal anyway)..not to speak of the unsatisfying results and loads of suffering and collateral damages to the body and actually healthy parts...

    When curing the cancers, people do live a longer time, get other illnesses which also need therapies and create more profits (cynically thought about in the name of profit)...

    No honestly, every 'real' physician should be grateful for this new discovery and I am sure really is ...must be frustrating to apply such dark age measures ...and watching how the patient suffers anyway causing much collateral damage.

    The team who lead this study is great. Thank you for your work in the name of science! :worthy:

    My dad has cancer and I will suggest this new drug so he can tell about it to his doctors IF his kind of cancer belongs to Mismatch Repair–Deficient caused cancers...cancers which pull the PD-1 on immune cells (for instance T helper cells) so they stop fighting against it.

    For all who like to know how it works (as I liked) here is a good presentation:
    It is nicely presented as always and illustrated with fumy drawings, loved it! Easy to understand for all those who love Biology and human cells and their interactions.

     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  6. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    WOW!!!!

    https://www.index.hr/vijesti/clanak...dyWiba-Wffp4MD4RaAfYqfIo7zQTNFUtPCOB2C3OKpEcE

     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  7. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  8. Yen

    Yen Admin
    Staff Member

    May 6, 2007
    13,081
    13,977
    340
    #1168 Yen, Jun 22, 2022
    Last edited: Jun 22, 2022
    The scientific work is fascinating, especially the imaging of stages of mitosis. It's been published at a top notch journal, Cell : The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin: Current Biology (cell.com)

    Anyway I have to say the headline of the 'Index' newspaper:"A team of Croatian scientists has discovered a cell mechanism that protects against cancer" does not match what they have discovered. It's still a hope for the future...
    They are still at the very beginning to understand about the chirality of the mitotic spindle. So it is an assumption that it might have an impact on the reproduction process of the chromosomes and potential failures.

    Look at the chain of reasoning: Errors in the steps (mitosis)--->errors may occur when the division spindle is formed---->errors like this can lead to various genetic defects such as cancer.

    In other words there is NO determination of what is different only at the process that leads to a cancer cell. They came up with left handed spindle twist as a factor, but also non-cancer immortalized epithelial cell line hTERT-RPE1 have shown that.

    It will be hard to determine a specific difference / attribute at those processes that clearly points out a process that leads to a cancer cell.
    This is a in vitro study and the cells used are cell-lines such as HeLa cells (those are associated to cervical cancer for instance) which have exactly determined biological attributes, attributes which also can be found at 'real / in vivo' human cancer cells.

    Anyway I do not diminish this work. It is great and I love the imaging of the processes at original Cell publication.
    I just wanted to slow down euphoria when it is associated to fight cancer, but I can understand that such a headline gets more clicks. But maybe it is a foundation of future works in this regard.:)



    Drones can deliver emergency medicine..but also......
    We all know the term "Dual Use" :(

    Even when you have 'single use' such as a weapon only (I do not mean a knife for instance).....there is still the idea of being useful in a way...
    Hmm a weapon such as a tank does nothing until it is used, and when it is used it only causes harm on living beings.
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  9. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    #1169 gorski, Jun 24, 2022
    Last edited: Jun 24, 2022
    Yes, the fundamental level of research is slow and seriously difficult. What is great is that it is going on, even in such "small" and "poor" centres, like Croatia - obviously, talent does not choose where to be born and "brain-drain" practices must be stopped, for the benefit of all. This is but one of those possible mechanisms...

    As far as their research is concerned, if *we* (Humans) eventually get the cause of different orientation and then what it actually means, i.e. how to avoid an/or guarantee it - well, it's a fabulous start!!!

    Science must be strictly controlled because of its power! *Defence* ministries (including of "security services") around the world in particular! These developments must be stopped ASAP!!!

    ALL the resources, from people to money, must be redirected to eliminating poverty, disease, hunger, ecological disasters etc.!!!

    All else is sociopathy incorporated = *Sociopaths R US*!!!!

    P.S. The online translation is not exactly 100%, btw. The lead researches explained that now they understand the mechanism that helps against a wrong chromosome division, which function as "cushioning" protecting against outside forces, which mechanism may be used to help with "individual medicine", I presume, when these mechanisms are important to return to normal health, if a person develops a cancer, for instance, due to the breakdown of this mechanism - if I got it right...
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  10. case-sensitive

    case-sensitive MDL Expert

    Nov 7, 2013
    1,680
    726
    60
    Capital owns the world , they own the system and we're their tennants / slaves / guinny pigs ........... the only reason for our existence is to serve and pay for them . Most science is either driven by their weapons industry or their health system = To be used by them , to their benefit , to keep us down and them in control .

    Good example is the medieval pariah state little britain where the whole legal system is designed to keep us down and them in power .
     
  11. Tiger-1

    Tiger-1 MDL Guru

    Oct 18, 2014
    7,897
    10,733
    240
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  12. Yen

    Yen Admin
    Staff Member

    May 6, 2007
    13,081
    13,977
    340
    Percentage of Heavy Drinking Days Following Psilocybin-Assisted Psychotherapy vs Placebo in the Treatment of Adult Patients With Alcohol Use Disorder: A Randomized Clinical Trial | Psychiatry and Behavioral Health | JAMA Psychiatry | JAMA Network

     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  13. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    #1173 gorski, Sep 12, 2022
    Last edited: Sep 12, 2022
    https://www.bbc.co.uk/news/health-62797777

    These issues are frequently intersections of many spheres of modern life, so here we have fossil fuel, pollution and more... Now, this breakthrough better be quick for oh so many of us...

    Air pollution cancer breakthrough will rewrite the rules

    By James Gallagher
    Health and science correspondent
    [​IMG]
    IMAGE SOURCE,GETTY IMAGES
    Researchers say they have cracked how air pollution leads to cancer, in a discovery that completely transforms our understanding of how tumours arise.

    The team at the Francis Crick Institute in London showed that rather than causing damage, air pollution was waking up old damaged cells.

    One of the world's leading experts, Prof Charles Swanton, said the breakthrough marked a "new era".

    And it may now be possible to develop drugs that stop cancers forming.

    The findings could explain how hundreds of cancer-causing substances act on the body.

    The classical view of cancer starts with a healthy cell. It acquires more and more mutations in its genetic code, or DNA, until it reaches a tipping point. Then it becomes a cancer and grows uncontrollably.

    But there are problems with this idea: cancerous mutations are found in seemingly healthy tissue, and many substances known to cause cancer - including air pollution - don't seem to damage people's DNA.

    So what is going on?

    The researchers have produced evidence of a different idea. The damage is already there in our cell's DNA, picked up as we grow and age, but something needs to pull the trigger that actually makes it cancerous.

    The discovery came from exploring why non-smokers get lung cancer. The overwhelming majority of lung cancers are caused by smoking but still, one in 10 cases in the UK is down to air pollution.

    The Crick scientists focused on a form of pollution called particulate matter 2.5 (known as PM2.5), which is far smaller than the diameter of a human hair.

    [​IMG]
    Through a series of detailed human and animal experiments they showed:

    • Places with higher levels of air pollution had more lung cancers not caused by smoking
    • Breathing in PM2.5 leads to the release of a chemical alarm - interleukin-1-beta - in the lungs
    • This causes inflammation and activates cells in the lungs to help repair any damage
    • But around one in every 600,000 cells in the lungs of a 50-year-old already contains potentially cancerous mutations
    • These are acquired as we age but appear completely healthy until they are activated by the chemical alarm and become cancerous
    Crucially, the researchers were able to stop cancers forming in mice exposed to air pollution by using a drug that blocks the alarm signal.

    The results are a double breakthrough, both for understanding the impact of air pollution and the fundamentals of how we get cancer.

    Dr Emilia Lim, one of the Crick researchers, said people who had never smoked but developed lung cancer often had no idea why.

    "To give them some clues about how this might work is really, really important," she said.

    "It's super-important - 99% of people in the world live in places where air pollution exceeds the WHO guidelines so it really impacts all of us."
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  14. case-sensitive

    case-sensitive MDL Expert

    Nov 7, 2013
    1,680
    726
    60
    Typical kamikazi capitalist science . Instead of stopping polution , keep producing it , but make medicines against it !?!? Same same with the climate cacktastrophy .
     
  15. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    Indeed, without a strategic stab at the causes of these diseases we're doomed...

    And entrenched interests are not letting go without the rest of us really pushing...
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  16. R29k

    R29k MDL GLaDOS

    Feb 13, 2011
    5,171
    4,811
    180
    SciTechDaily: Scientists Have Developed a New Explanation for Consciousness.
    https://scitechdaily.com/scientists-have-developed-a-new-explanation-for-consciousness/

    Ars Technica: How Google alerted Californians to an earthquake before it happened.
    https://arstechnica.com/science/202...-an-earthquake-before-it-happened/?comments=1

    Ars Technica: How a Microsoft blunder opened millions of PCs to potent malware attacks.
    https://arstechnica.com/information...ed-millions-of-pcs-to-potent-malware-attacks/

    ScienceAlert: Strange Ripples Have Been Detected at The Edge of The Solar System.
    https://www.sciencealert.com/strange-ripples-have-been-detected-at-the-edge-of-the-solar-system

    Space.com: Hubble Space Telescope finds star collision's jet travels fast.
    https://www.space.com/hubble-space-telescope-neutron-star-collision-jet/

    yahoo.com: Earth May Have a Hidden Sixth Ocean.
    https://www.yahoo.com/video/earth-may-hidden-sixth-ocean-160023053.html

    Space.com: Mysterious reflections on Mars might come from something stranger than water.
    https://www.space.com/mars-lake-reflection-rock-layering-alternative/

    Phys.org: Artificial intelligence reduces a 100,000-equation quantum physics problem to only four equations.
    https://phys.org/news/2022-09-artificial-intelligence-equation-quantum-physics.html

    Phys.org: Researchers answer fundamental question of quantum physics.
    https://phys.org/news/2022-09-fundamental-quantum-physics.html

    NPR: Scientists have found a mineral stronger than diamond.
    https://www.npr.org/2022/09/18/1123689572/scientists-have-found-a-mineral-stronger-than-diamond
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  17. R29k

    R29k MDL GLaDOS

    Feb 13, 2011
    5,171
    4,811
    180
    Livescience.com: Scientists want to build an 'interstellar interceptor' to play hide-and-seek with the next 'Oumuamua.
    https://www.livescience.com/interstellar-interceptor-plans/

    SciTechDaily: 300 Years of Research: Princeton Scientists Solve a Bacterial Mystery.
    https://scitechdaily.com/300-years-of-research-princeton-scientists-solve-a-bacterial-mystery/

    USA TODAY: What's the coldest planet in the solar system? What about in the known universe?.
    https://www.usatoday.com/story/news...anet-solar-system-known-universe/10623483002/

    SciTechDaily: Strict Parenting May Hardwire Depression Into a Child’s DNA.
    https://scitechdaily.com/strict-parenting-may-hardwire-depression-into-a-childs-dna/

    Livescience.com: 4.6 billion-year-old meteorite may reveal the origin of Earth's water.
    https://www.livescience.com/uk-driveway-asteroid-could-explain-ocean-origins/

    Livescience.com: What was the US military's secret space plane doing on its record-breaking mission?.
    https://www.livescience.com/spaceplane-lands-after-908-days-orbit/

    ScienceAlert: JWST Peers Deep Into The Universe's Early Galaxies, Revealing Something Surprising.
    https://www.sciencealert.com/jwst-p...early-galaxies-revealing-something-surprising

    Space.com: LightSail 2 spacecraft ends its solar-sailing mission in a blaze of glory.
    https://www.space.com/lightsail-2-solar-sailing-mission-ends/

    Futurism: Amazing Map Lets You Scroll Through the Entire Known Universe.
    https://futurism.com/the-byte/amazing-map-scroll-known-universe

    yahoo.com: First view of moon from NASA’s Orion spacecraft.
    https://www.yahoo.com/news/first-view-moon-nasa-orion-235108007.html


    Ars Technica: New test shows loose RTX 4090 power connectors cause overheating and melting.
    https://arstechnica.com/gadgets/202...wer-connectors-cause-overheating-and-melting/

    SciTechDaily: Warning: Popular Vitamin Supplement Causes Cancer Risk and Brain Metastasis.
    https://scitechdaily.com/warning-popular-vitamin-supplement-causes-cancer-risk-and-brain-metastasis/
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  18. Bat.1

    Bat.1 MDL Expert

    Oct 18, 2014
    1,200
    1,387
    60
    lobotomy11 hack R2 Tag :fear2:
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  19. gorski

    gorski MDL Guru

    Oct 21, 2009
    5,514
    1,452
    180
    https://www.theguardian.com/society...pon-antibiotic-war-against-bacteria-albicidin

    Plant toxin hailed as ‘new weapon’ in antibiotic war against bacteria
    Scientists say albicidin has allowed them to take a giant step forward to creating a powerful new range of antibacterial drugs

    [​IMG]
    Albicidin, a potent plant toxin with a unique way of killing harmful bacteria, has emerged as one of the strongest antibiotic candidates in decades.
    Scientists have discovered a plant toxin whose unique method of dispatching bacteria could be used to create a powerful new range of antibiotics. The prospect of developing new antibacterial drugs this way has been hailed by doctors, who have been warning for many years that the steady rise of multidrug-resistant pathogens such as E coli now presents a dangerous threat to healthcare across the planet.

    The new antibiotic – albicidin – attacks bacteria in a completely different way to existing drugs, a group of British, German and Polish scientists have revealed in a paper recently published in the journal Nature Catalysis. This suggests a new route could be exploited to tackle bacterial disease, they say.

    “We could not elicit any resistance towards albicidin in the laboratory,” said Dmitry Ghilarov, whose research group is based at the John Innes Centre in Norwich. “That is why we are really excited – because we think it will be very hard for bacteria to evolve resistance against albicidin-derived antibiotics.”

    Albicidin is produced by a bacterial plant pathogen called Xanthomonas albilineans that triggers a devastating disease, known as leaf scald, in sugarcane. The pathogen uses albicidin to attack the plant, but it was also found, several decades ago, that it was highly effective at killing bacteria.

    “The problem was that, at the time, we did not know exactly how albicidin attacked bacteria and so we could not use it as the basis of new antibiotics because these might have triggered all sorts of complications in the human body,” said Ghilarov. “We had to determine precisely how it killed bacteria before we could do that – and that is what we have now achieved.”
     
    Stop hovering to collapse... Click to collapse... Hover to expand... Click to expand...
  20. case-sensitive

    case-sensitive MDL Expert

    Nov 7, 2013
    1,680
    726
    60