I too have switched from LM22 to LMDE6, I switched due to driver issues with my Nvidea card, I bit the bullet and picked up a cheap AMD card but I can see no reason to switch back to regular Mint. Can I say again that Spiral Linux Cinnamon edition is also a great alternative to Mint, the Debian extended long term support provided by Spiral is a major bonus.
A short update on the upgrade process to Fedora 41. I decided to go via terminal to have a look what's actually going on. Normally you can start the upgrade process within the discover app (GUI)... It all went smoothly without any issues. Afterwards I had a look at the system to see if there is something else left to do (cleaning old stuff, etc). There was no garbage left. I did revert some system configs to the package maintainer's default, though. I also updated my rescue kernel to ver. 41 manually and the bootloader to the latest as well. I am still impressed by Fedora. Plugged in a new QDOLED monitor, Fedora recognized it and my dimming (brightness control) / HDR and FreeSync settings worked out of the box. There is only one downside. As being said....there is always a lot of stuff to be downloaded as updates. My biggest one had been 6.4 GB after some weeks. This is actually far more than an entire new ISO image of the OS itself.