The 2 major reasons why the mRNA technology could not be established earlier is the general instability of the mRNA itself and how to make it entering the cell's cytoplasm as a whole. mRNA is a messenger that normally works inside the cell. Free floating mRNA is decomposed by RNases very quickly. Before you donate blood you have to list any medications either way. Within the vaccination period it is generally not advisable to donate blood. (It stresses the body additionally). Free mRNA is not an issue. You cannot filter it out, though. It does not survive within the blood sample. Besides of that when getting the vaccine it actually does not enter the bloodstream. It is an intramuscular injection when done properly. Another point would be (immune)cells already producing / presenting the antigen. If you'd get them from a blood donation you actually get a sort of a very tiny vaccination since the antigen is presented to your body. And not to forget there is treatment using convalescent plasma! (plasma is anything of blood except all the cells). By that you get antibodies against SARS-Cov-2 which you also would get by blood donation from somebody who has active antibodies. But ab's also have got a very unique part at creation (depends on personal DNA) and that is the reason why convalescent plasma does not work that well, except your factors do match well to those of the donator... The issue mRNA integrity at the vaccines. Well I rather would expect quantity issues due to the fact that mRNA is not stable. mRNA do have a head and a tail. (3' and 5'). They are 'formatted' and within there is the 'data' which is translated into the corresponding (s) protein. You can compare it to storage tech of well HDDs where is a header. Once it's broken the ribosomes cannot work on it anymore and reject the translation. I talked to a doc. She said mRNA vaccines are very sensitive. Not to temperature alone, but also to shock. The nano lipids can burst if shaken a lot... So I expect an issue with quantity. (Also if the cool-chain is interrupted) ..some people might have a lower efficacy without to know it... Quality control when it leaves the place of manufacturing alone doesn't say anything about that...
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine https://pubs.acs.org/doi/10.1021/acscentsci.1c00080 Shedding: turns out now vaxxed people could infect non-vaxxed with such spike protein if shedding occurs. See pinky? Now you're going to hurt those around you. You are helpless now silly.
I think you need elementary logic lessons.... But OK, who am I to stop you from embarrassing yourself freely - and publicly so...?!?
No of course not! This is an example of plain misunderstanding of the article. You quoted a bit of a detail of the spike fusion mechanism to ACE2! The word 'shedding' is fully out of context. It does not mean to shed the S1 subunit to another person, nor to shed spike proteins created from vaccines to others! (Which is not possible at mRNA or vector based vaccines since they are made within a cell!) To shed means here = to get rid of / ditch. The mechanism how it enters a cell is very detailed. This is for the pros and anybody who want to know any detail: https://www.pnas.org/content/pnas/114/42/11157.full.pdf Check fig.5! " Proposed model of coronavirus entry." And the term 'population' is NOT related to 'humans'. Just search for it and you'll see. "The pie charts summarize the mass spectrometric analysis of the oligomannose/hybrid (green), complex (pink), or unoccupied (gray) N-linked glycan populations. " The point of interest concerning invention is what they found out at previous SARS and MERS vaccine development. The conformation of the s protein plays a major role. The prefusion form is most beneficial. They stabilized using artificial 'mutations' by inserting proline. I posted about that. It's been made to even avoid this shedding "To this end, many vaccine candidates include (two or more) stabilizing mutations in the S protein, such that the protein maintains the prefusion conformation and avoids shedding of S1.(3)" AFAIK the AZ vector does not contain this proline mutation and hence it behaves just like the wild type infection means also sheds the S1 subdomain to other populations. IF this is beneficial or not...they tried to figure. BTW: Here some more: https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behind-COVID-19/98/i38
Yes, perhaps I misunderstand this and many other things but I don't won't trust any science or technology messing with the sancta sanctorum of life. Messing with God's creation lol what an arrogance. Unbelievable. Of course everything starts from the ideology one has.
It's fine to stay sceptical. I posted how I got it. Also open for discussions. I am not unerring all the time, just human. What has to be pointed out IS that the mRNA vaccine makers have fiddled with the spike protein. They inserted proline and call it artificial 'mutation' / modification. Their goal is to stabilize a special conformation (prefusion form of the spike) in order to make it more active to the immune system. Here I mentioned the proline modification which attracted my very attention already. My oversight of vaccines: https://forums.mydigitallife.net/threads/coronavirus-discussion.81224/page-86#post-1636635 One can clearly notice that the term 'mutation' is OK in this context, BUT when they talk about natural mutations such as variants it is evil! The vaccines have a clear pro bias and that is a sign which reasons being sceptical! At the other link they administered a huge amount of S protein to mice and could show damage. Fine. But we also have to relate it to what is happening at either a natural SARS-CoV-2 infection and / or vaccination and compare to the experiment with the mice. And then we have to discuss how is a probable relation. We need the scientific discourse and not unreasonable pro vaccine statements all the time. So you are right checking anything.
How's this for crazy. https://www.zerohedge.com/medical/w...leven-dallas-randomly-vaccinate-younger-crowd Troops go into a bar and offer to vaccinate people, that have been drinking, might be drunk. What could possible go wrong? I thought the " vaccines" had to be stored carefully, and administered by trained people. It's hard to see how proper screening was done to people drinking in a bar. I guess the mandatory rest period after the jab is to belly up to the bar and have a cold one to see if you have an adverse reaction to the jab. .
Yes it's unbelievable. In the meantime I have made a clear personal decision. I definitely will not go for the vaccination, also not when a vaccine (such as Novavax which is my fav. due to medical reasons) will be available. It's become more and more a political and ethical decision, rather than a medical. I do not want to become a part of this. I want to remain on the other 'side' belonging to those who denied it. Booster injection. Yes sure you need one, it brings in the money!. There is absolutely no medical reasoning yet! And yes administering a jab in a bar by a f***ing soldier while people can be drunken?!? WTF? This is no kids game, it's administering an experimental vaccine that only has EUA!!! And they also push now parents to let vaccinate kids also! This is against Nuremberg Code / Hippocratic oath and many more. Later when this gets worked off I want to say I wasn't part of it and I wasn't a supporter.
I see that all the arguments revolve around people who have not been vaccinated and people who have been vaccinated. And now those who haven't been vaccinated are waiting for people who have been vaccinated to die! And those who have been vaccinated want to justify themselves with the false facts that have been foisted on them about the benefits of vaccination! You guys at least hang yourselves with calculations of figures of statistics of what incomprehensible kind? There is a fact of 4 countries Russia - Ukraine - Canada - USA have official documents from the Ministries of Health that the corona virus has not been detected and it does not exist in nature! What does everybody vaccinate themselves against, jeopardizing their health? It is not clear.
You should listen to yourself, to your own advice! When you, MrX and alike do that - OK... And not just formally but substantially!
Do you have a link to those documents? I mean to most of us SARS-CoV-2 is just an abstract term, and 'existence' and 'proven existence'. Finally when recognizing something as such own perception and categorisation play a major role. I don't get a sense at arguing it does not exist as such, though. There is cause and an undeniable effect. When saying: "..the corona virus has not been detected and it does not exist in nature!" one has to have an idea of 'the corona virus'. It leads to nothing. Then call the cause: The thing that makes people sick and is spreading and can be differentiated by lab methods...?!? You can detect parts of a foreign sequence and you can sequence an entity (around 30,000 amino acids) which is called SARS-CoV-2 and you can notice that this sequence is changing during time AKA variations. By doing that it hijacks human cells and destroys tissue and is spreading from one individual to others, most have a cross immunity being asymptomatic, others don't. So what is IT?
HOW IS THIS POSSIBLE? I haven't been infected by SARS-CoV-2 and get covid since all this started. Neither my wife (46) nor my two beloved children (19 yrs man and 14 yrs girl). Healthy as a broccoli lol, especially my daughter who hasn't got a single flu or cold since she was 2. She was breastfed until 5 yrs with real mother's colostrum. We don't do stupid social distancing. We sell street food on a nearby populated street. We don't use muzzles at all except where required or enforced such as banks supermarkets, etc. We don't wear "mouthpads" even on public transport where risks of contagion is skyrocketed. There's a regulation to wear them inside the bus but some people disobey yet drivers won't complain, hey they even don't wear one at all lol Here's Mexico where law and rules were made to be broken. Impunity is our flagship roflmao
Survival of the fittest? Our best scientists, artists, doctors and so on have been "genetically flawed" - as is your "thinking"....
https://www.theguardian.com/science...tm_source=esp&utm_medium=Email&CMP=GTUK_email Extremely worrying!