Coronavirus | Discussion

Discussion in 'Serious Discussion' started by Deleted member 1254778, Feb 28, 2020.

  1. Tiger-1

    Tiger-1 MDL Guru

    Oct 18, 2014
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    hi Mr.X thanks for the post very good info :tankyou:
     
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  2. Mr.X

    Mr.X MDL Guru

    Jul 14, 2013
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  3. R29k

    R29k MDL GLaDOS

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    Oooh loook @Mr.X is taking old data that has been sensationalized by propaganda sites and running with it.... Whats new?

    Have a look here
    https://www-zentrum--der--gesundhei...sl=auto&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=nui

    Prof. Schirmacher makes it clear that he does not want to spread panic, that he is not an opponent of the vaccine and that he himself has been vaccinated against Corona. Nevertheless, he is of the opinion that one must weigh up the medical reasons for vaccination individually.

    Original link is here https://www.zentrum-der-gesundheit.de/news/gesundheit/covid-19/corona-todesfaelle
     
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  4. Palladin

    Palladin MDL Senior Member

    Feb 1, 2014
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    This is a very complete video on Ivermectin and goes into great detail as to exactly how it works down to the molecular level.

    Even though he is somewhat against using Ivermectin for Covid-19, it's still worth watching to see the complicated mechanism that goes into how a virus infects the host.



    If you find it informative, you might want to download it, since YouTube might pull it at any time without any warning.

    .
     
  5. Yen

    Yen Admin
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    #3305 Yen, Sep 29, 2021
    Last edited: Sep 29, 2021
    I just found something useful, useful for everyone.

    Namely info on how to get COVID risk factors and by that data for a proper individual risk/benefit analyses for the vaccines.

    "Underlying Medical Conditions and Severe Illness Among 540,667 Adults Hospitalized With COVID-19, March 2020–March 2021"
    https://www.cdc.gov/pcd/issues/2021/21_0123.htm

    So to all who have a problem and are pointing on those unvaxxed and are spreading further fear or any form of patronization.....they should be aware that one could also point to the obese.

    Also anxiety (fear mongering) is very contra productive....

    At least then everybody should be clear that pointing with fingers is no appropriate human behavior.
     
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  6. gorski

    gorski MDL Guru

    Oct 21, 2009
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    Anxiety could be related to getting vaccinated, too....
     
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  7. Yen

    Yen Admin
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    #3307 Yen, Sep 30, 2021
    Last edited: Sep 30, 2021
    I have a new favorite vaccine (candidate) SCB-2019 from Clover. (Within all COVID vaccines, does not mean that I advocate those vaccines, though).
    https://www.pharmaceutical-technology.com/features/clover-covid-19-vaccine-global-supply/

    A protein based antigen also (such as Novavax) but based on a well known aluminium based adjuvant (CpG 1018/Alum).

    This is actually similar to the German Stöcker vaccine. (AFAIK Stöcker uses RBD, though).

    It's for those who strictly deny a tech without long term safety data, but still want a vaccine which can rely on former scientific experience, because this type of vaccine and the adjuvant are well known.

    Here is the presentation (be aware company presentations do always come with bias).

    IMHO it's a relatively good one. The odd thing is, though, it's also still based on the old Wuhan spike. It has the advantage to Novavax that their adjuvant is new (Matrix M) and the one of Clover is well known (Alum)
    https://www.cloverbiopharma.com/upload/pdf/SPECTRA-Data-Presentation_2021.09.22_FINAL_EN.pdf
     
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  8. gorski

    gorski MDL Guru

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    Indeed, loads of journalists simply take what companies/governments hand out as press releases and call that "journalism" and "their articles"...
     
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  9. Yen

    Yen Admin
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    Even medical journals are affected in the meantime.
    They rather 'accept' studies on new stuff where's big money behind than studies on off-patent drugs.
     
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  10. Palladin

    Palladin MDL Senior Member

    Feb 1, 2014
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    Well what do you know.
    There's a new player on the block with a vaccine for Covid-19

    https://www.merck.com/news/merck-an...to-placebo-for-patients-with-mild-or-moderat/

    No information as to long term safety side effects, no information as to how it works, what it will cost, or detailed listing of the ingredients, but the MSM loves it and calls it a "Game Changer".

    FWIW, Merck was the drug company that first developed and patented Ivermectin.

    And of course the government wants to buy lots of it.
    https://www.hhs.gov/about/news/2021...al-antiviral-medicine-covid-19-treatment.html

    .

    .
     
  11. gorski

    gorski MDL Guru

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    At over $700 per course...

    Must be taken early or else...

    Previous antivirals never worked because one doesn't know one is infected when one must take it, very early on... A nice money-maker...
     
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  12. Yen

    Yen Admin
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    #3312 Yen, Oct 2, 2021
    Last edited: Oct 2, 2021
    I have already posted about Merck's Molnupiravir.

    It targets RdRp, an enzyme which is needed for viral (RNA) replication.
    Molnupiravir delivers 'fake bricks' to the RdRp which it uses then to replicate viral RNA.

    As result there is a viral mutation which causes the new virus to be disabled. (In theory).
    IVM also targets RdRp, but IVM has at least 4 other additional mechanisms of action. IVM doesn't deliver those fake bricks but disrupts the RdRp enzyme itself. And it also has anti-inflammatory properties, since the critical phase at COVID is a process of inflammation, an unique benefit.

    AFAIK Merck developed Molnupiravir against influenza, which is also a RNA virus. But never got it there.
    It is really ironic, that especially Merck who also developed IVM comes now up with Molnupiravir, promoting it as game changer.

    There is only one reason. It is new and still under patent. But their own IVM is far superior. Off-patent, no money to make.

    Yeah, well. Who could know that an anti-parasite can have several mechanisms against SARS-COV-2? When they developed IVM there was no COVID yet.

    But to suppress their own IVM while promoting new stuff.....is more than questionable.
    It costs lives, whether Molnupiravir becomes a game changer or not.....it takes time...
     
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  13. Palladin

    Palladin MDL Senior Member

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    The MSM is acting as if this Merck announcement is "News" but as you have stated in this thread from June of this year: https://forums.mydigitallife.net/threads/coronavirus-discussion.81224/page-133#post-1667156
    See your Post #2644

    Then there's this from about the same June time frame echoing what you said:
    https://www.fiercepharma.com/pharma...-finally-provide-effective-covid-19-treatment
    So all this MSM hoopla is really old news from 6 months ago with Merck supplying a new twist to the old results.

    .
     
  14. Yen

    Yen Admin
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    #3314 Yen, Oct 2, 2021
    Last edited: Oct 2, 2021
    For all who are interested.
    To the question "ingredients".

    Molnupiravir is a single drug. A certain organic molecule.
    It looks like:
    [​IMG]

    It acts as a pro-drug, means the body synthesizes the active drug itself from it. This active drug then delivers 'fake bricks' to the enzyme that is responsible for viral RNA replication. It's called RdRp.
    It's like you are building a house. But someone sabotages your intend delivering faulty bricks. As result your house will be useless.

    IVM looks like this:
    [​IMG]

    It is also a drug, but it consists of 2 similar molecules. Additionally it is assumed that the body synthesizes a great variety of other drugs from them which even have got a longer half life.
    The effect on RdRp is different.
    Instead of delivering fake bricks it disrupts the RdRp itself.

    You are building your house with good bricks, but your work power is sabotaged. But this is one of at least 4 different mechanisms only.

    Everyone can notice that IVM is a more complex molecule. This usually comes along with a greater variety of different mechanisms of actions.

    So people who are laughing about a horse de-wormer being good against SARS-CoV-2 don't have a clue about pharmacology at all.
    Molecules can have different pharmacological attributes. And since this is more complex, the variety is also more complex.

    I tried to use simple terms. For those who are pro, I am aware that this post is very simplified.
    Enjoy. :)

    Edit: Source of molecules is Wikipedia.
     
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  15. Mr.X

    Mr.X MDL Guru

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  16. R29k

    R29k MDL GLaDOS

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  17. gorski

    gorski MDL Guru

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    Since we like graphs, here's a current one, also...

    GOP and C19.jpg

    One gal said: "Show me where Republicans live without showing me where Republicans live..."
     
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  18. Mr.X

    Mr.X MDL Guru

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    What are you waiting for, go get vaccinated. Go before it's too late.
     
  19. gorski

    gorski MDL Guru

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    Perhaps hallucinogens and similar compounds do not benefit you after all...???
     
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  20. R29k

    R29k MDL GLaDOS

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    One issue, the lower States like louisiana, missouri etc. They have poorer miniority populations that are a) vaccine hesitant and b) have poor diets.
     
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